ArticleJournal of neural transmission (Vienna, Austria : 1996)2015
Assessment of the degree of asymmetry of pathological features in neurodegenerative diseases. What is the significance for brain banks?
Article in Journal of neural transmission (Vienna, Austria : 1996), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Variations of global brain asymmetry are associated with aging and related diseases.Science advances · 2026Article
- Amygdalar and hippocampal volume loss in limbic-predominant age-related TDP-43 encephalopathy.Brain : a journal of neurology · 2025Article
- Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer's Disease.Nature communications · 2025Article
- Association of Seizure Foci and Location of Tau and Amyloid Deposition and Brain Atrophy in Patients With Alzheimer Disease and Seizures.Neurology · 2024Article
- Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer's disease.Brain, behavior, and immunity · 2024Article
- Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Prevalence, distribution, and severity of cerebral amyloid angiopathy differ between Lewy body diseases and Alzheimer's disease.Acta neuropathologica communications · 2024Article
- Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer`s disease.medRxiv : the preprint server for health sciences · 2023Article
- Findings ofNeuropsychopharmacology reports · 2022Article
- Hemispheric Asymmetry and Atypical Lobar Progression of Alzheimer-Type Tauopathy.Journal of neuropathology and experimental neurology · 2022Article
- Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology.Acta neuropathologica communications · 2021Article
- Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.Acta neuropathologica communications · 2021Article
- The enigma and implications of brain hemispheric asymmetry in neurodegenerative diseases.Brain communications · 2021Review
- Quantitative patterns of motor cortex proteinopathy across ALS genotypes.Acta neuropathologica communications · 2020Article
- Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia.Brain : a journal of neurology · 2018Article
- Cortical laminar tau deposits and activated astrocytes in Alzheimer's disease visualised byScientific reports · 2017Article
- Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans.Journal of visualized experiments : JoVE · 2016Article
- Higher Prevalence of TDP-43 Proteinopathy in Cognitively Normal Asians: A Clinicopathological Study on a Multiethnic Sample.Brain pathology (Zurich, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Brain banks allow researchers access to tissue from well-characterised neurodegenerative disease cases. Fixed tissue employed for diagnosis is often not appropriate for research and frozen tissue is therefore made available. Many brain banks use a protocol where half the brain is fixed and half frozen. Recently a study has shown that there can be asymmetry in protein deposition between the hemispheres especially with tau and TDP-43. We aimed to test this hypothesis by prospectively taking bilateral cortical blocks from 30 brains on arrival, and immunostaining to assess the degree of asymmetry. In 6 out 14 cases of AD (Alzheimer's Disease) (Modified Braak Stage V-VI), there was some asymmetrical staining for tau. In 2 cases, there was moderate discrepancy for tau staining between left and right calcarine cortices. However, careful analysis in both these cases revealed discrepancies in tau staining in adjacent regions even on the same side. The α-synuclein staining showed asymmetry in one case only, the Aβ showed only mild asymmetry in 3 cases of AD. The TDP-43 pathology appeared symmetrical in the 2 cases of frontotemporal lobar degeneration with motor neurone disease, but there was asymmetry noted when seen in conjunction with AD. In conclusion, there is the potential for asymmetrical pathology in neurodegenerative diseases and caution should be maintained when freezing half and fixing half of the brain in neurodegenerative diseases. Nevertheless, marked variability in staining can also be identified in adjacent cortical areas so there is no guarantee that an alternative strategy would be superior.
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