ArticleCerebral cortex (New York, N.Y. : 1991)2015
Serotonin Attenuates Feedback Excitation onto O-LM Interneurons.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function.Hippocampus · 2025Article
- Deciphering the Functions of Raphe-Hippocampal Serotonergic and Glutamatergic Circuits and Their Deficits in Alzheimer's Disease.International journal of molecular sciences · 2025Review
- Differential Serotonergic Modulation of Principal Neurons and Interneurons in the Anterior Piriform Cortex.Frontiers in neuroanatomy · 2022Article
- Generation of Sharp Wave-Ripple Events by Disinhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Presynaptic GABAeLife · 2020Article
- Computationally going where experiments cannot: a dynamical assessment of dendritic ion channel currents duringF1000Research · 2020Article
- Single-cell RNA-Seq characterization of anatomically identified OLM interneurons in different transgenic mouse lines.The European journal of neuroscience · 2019Article
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Activation mechanism of a neuromodulator-gated pacemaker ionic current.Journal of neurophysiology · 2017Article
- Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo.Brain structure & function · 2017Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The serotonergic system is a subcortical neuromodulatory center that controls cortical information processing in a state-dependent manner. In the hippocampus, serotonin (5-HT) is released by ascending serotonergic fibers from the midbrain raphe nuclei, thereby mediating numerous modulatory functions on various neuronal subtypes. Here, we focus on the neuromodulatory effects of 5-HT on GABAergic inhibitory oriens lacunosum-moleculare (O-LM) cells in the hippocampal area CA1 of the rat. These interneurons are thought to receive primarily local excitatory input and are, via their axonal projections to stratum lacunosum-moleculare, ideally suited to control entorhinal cortex input. We show that 5-HT reduces excitatory glutamatergic transmission onto O-LM interneurons. By means of paired recordings from synaptically connected CA1 pyramidal cells and O-LM interneurons we reveal that this synapse is modulated by 5-HT. Furthermore, we demonstrate that the reduction of glutamatergic transmission by serotonin is likely to be mediated via a decrease of calcium influx into presynaptic terminals of CA1 pyramidal cells. This modulation of excitatory synaptic transmission onto O-LM interneurons by 5-HT might be a mechanism to vary the activation of O-LM interneurons during ongoing network activity and serve as a brain state-dependent switch gating the efficiency of entorhinal cortex input to CA1 pyramidal neurons.
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