ArticleAJNR. American journal of neuroradiology2015
Influence of Resting-State Network on Lateralization of Functional Connectivity in Mesial Temporal Lobe Epilepsy.
Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Resting-state fMRI seizure onset localization meta-analysis: comparing rs-fMRI to other modalities including surgical outcomes.Frontiers in neuroimaging · 2024Pooled it
- Dynamic Analysis of Gray Matter and White Matter Functional Network Connectivity in Individuals with Temporal Lobe Epilepsy.Research square · 2026Article
- Seizure-onset zone lateralization in temporal lobe epilepsy using 7T rs-fMRI: Direct comparison with 3T rs-fMRI.Epilepsia · 2025Article
- Structural brain network analysis in occipital lobe epilepsy.BMC neurology · 2023Article
- Comparison of multimodal findings on epileptogenic side in temporal lobe epilepsy using self-organizing maps.Magma (New York, N.Y.) · 2022Article
- Verbal Learning and Longitudinal Hippocampal Network Connectivity in Temporal Lobe Epilepsy Surgery.Frontiers in neurology · 2022Article
- Spatiotemporal evolution of epileptic seizure based on mutual information and dynamic brain network.BMC medical informatics and decision making · 2021Article
- Dynamic functional connectivity in temporal lobe epilepsy: a graph theoretical and machine learning approach.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Dynamical Mechanisms of Interictal Resting-State Functional Connectivity in Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Hubs disruption in mesial temporal lobe epilepsy. A resting-state fMRI study on a language-and-memory network.Human brain mapping · 2020Article
- Resting fMRI as an alternative for task-based fMRI for language lateralization in temporal lobe epilepsy patients: a study using independent component analysis.Neuroradiology · 2019Article
- Epileptic foci localization based on mapping the synchronization of dynamic brain network.BMC medical informatics and decision making · 2019Article
- Hub Patterns-Based Detection of Dynamic Functional Network Metastates in Resting State: A Test-Retest Analysis.Frontiers in neuroscience · 2019Article
- Resting state fMRI: A review on methods in resting state connectivity analysis and resting state networks.The neuroradiology journal · 2017Review
- Dynamic functional network connectivity in idiopathic generalized epilepsy with generalized tonic-clonic seizure.Human brain mapping · 2017Article
- Whole-brain analytic measures of network communication reveal increased structure-function correlation in right temporal lobe epilepsy.NeuroImage. Clinical · 2016Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeAlthough most studies on epilepsy have focused on the epileptogenic zone, epilepsy is a system-level disease characterized by aberrant neuronal synchronization among groups of neurons. Increasingly, studies have indicated that mesial temporal lobe epilepsy may be a network-level disease; however, few investigations have examined resting-state functional connectivity of the entire brain, particularly in patients with mesial temporal lobe epilepsy and hippocampal sclerosis. This study primarily investigated whole-brain resting-state functional connectivity abnormality in patients with mesial temporal lobe epilepsy and right hippocampal sclerosis during the interictal period. MATERIALS AND
methodsWe investigated resting-state functional connectivity of 21 patients with mesial temporal lobe epilepsy with right hippocampal sclerosis and 21 neurologically healthy controls. A multivariate pattern analysis was used to identify the functional connections that most clearly differentiated patients with mesial temporal lobe epilepsy with right hippocampal sclerosis from controls.
resultsDiscriminative analysis of functional connections indicated that the patients with mesial temporal lobe epilepsy with right hippocampal sclerosis exhibited decreased resting-state functional connectivity within the right hemisphere and increased resting-state functional connectivity within the left hemisphere. Resting-state network analysis suggested that the internetwork connections typically obey the hemispheric lateralization trend and most of the functional connections that disturb the lateralization trend are the intranetwork ones.
conclusionsThe current findings suggest that weakening of the resting-state functional connectivity associated with the right hemisphere appears to strengthen resting-state functional connectivity on the contralateral side, which may be related to the seizure-induced damage and underlying compensatory mechanisms. Resting-state network-based analysis indicated that the compensatory mechanism among different resting-state networks may disturb the hemispheric lateralization.
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