ArticleNature communications2015
Multisensory training reverses midbrain lesion-induced changes and ameliorates haemianopia.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Multisensory Stimulation to Improve Low- and Higher-Level Sensory Deficits after Stroke: A Systematic Review.Neuropsychology review · 2016Pooled it
- The brain can develop conflicting multisensory principles to guide behavior.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The Development of Multisensory Integration at the Neuronal Level.Advances in experimental medicine and biology · 2024Article
- Cross-modal exposure restores multisensory enhancement after hemianopia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Ameliorating Hemianopia with Multisensory Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Face shape processingFrontiers in neuroscience · 2022Article
- Review
- Association Cortex Is Essential to Reverse Hemianopia by Multisensory Training.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- An Audiovisual 3D-Immersive Stimulation Program in Hemianopia Using a Connected Device.The American journal of case reports · 2021Article
- Using the Principles of Multisensory Integration to Reverse Hemianopia.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Using superior colliculus principles of multisensory integration to reverse hemianopia.Neuropsychologia · 2020Article
- Reversing Hemianopia by Multisensory Training Under Anesthesia.Frontiers in systems neuroscience · 2020Article
- Interhemispheric visual competition after multisensory reversal of hemianopia.The European journal of neuroscience · 2019Article
- Ripe for solution: Delayed development of multisensory processing in autism and its remediation.Neuroscience and biobehavioral reviews · 2018Review
- The normal environment delays the development of multisensory integration.Scientific reports · 2017Article
- Pulsed Stimuli Elicit More Robust Multisensory Enhancement than Expected.Frontiers in integrative neuroscience · 2017Article
- Audiovisual Rehabilitation in Hemianopia: A Model-Based Theoretical Investigation.Frontiers in computational neuroscience · 2017Article
- Development and Implementation of a New Telerehabilitation System for Audiovisual Stimulation Training in Hemianopia.Frontiers in neurology · 2017Article
- Multisensory-Based Rehabilitation Approach: Translational Insights from Animal Models to Early Intervention.Frontiers in neuroscience · 2017Review
- Compensatory Recovery after Multisensory Stimulation in Hemianopic Patients: Behavioral and Neurophysiological Components.Frontiers in systems neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Failure to attend to visual cues is a common consequence of visual cortex injury. Here, we report on a behavioural strategy whereby cross-modal (auditory-visual) training reinstates visuomotor competencies in animals rendered haemianopic by complete unilateral visual cortex ablation. The re-emergence of visual behaviours is correlated with the reinstatement of visual responsiveness in deep layer neurons of the ipsilesional superior colliculus (SC). This functional recovery is produced by training-induced alterations in descending influences from association cortex that allowed these midbrain neurons to once again transform visual cues into appropriate orientation behaviours. The findings underscore the inherent plasticity and functional breadth of phylogenetically older visuomotor circuits that can express visual capabilities thought to have been subsumed by more recently evolved brain regions. These observations suggest the need for reevaluating current concepts of functional segregation in the visual system and have important implications for strategies aimed at ameliorating trauma-induced visual deficits in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.