ReviewThe Journal of endocrinology2015
Macronutrients and caloric intake in health and longevity.
Abstract readReview
In one paragraph
Review in The Journal of endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed.
- Trial
- Integrated behavioral and metabolically flexible responses of wild orangutans to ecologically driven dietary variation.Science advances · 2025Article
- Association of Low Protein-to-Carbohydrate Energy Ratio with Cognitive Impairment in Elderly Type 2 Diabetes Patients.Nutrients · 2024Article
- Impact of Intermittent Fasting and Dietary Restriction on Redox State, Energetic Metabolism, and Liver Injury in Common Bile Duct Ligation Model.Antioxidants (Basel, Switzerland) · 2024Article
- Differential Association of Dietary Linoleic Acid and Alpha-linolenic Acid with Adipose Tissue in a Sample of Iranian Adults; A Cohort-based Cross-sectional Study.Galen medical journal · 2023Article
- Agronomic Behavior of Mexican Roselle Cultivars Produced under Protected Agricultural Conditions.Plants (Basel, Switzerland) · 2022Article
- Temporal Dynamics of the Intestinal Microbiome Following Short-Term Dietary Restriction.Nutrients · 2022Article
- The ups and downs of caloric restriction and fasting: from molecular effects to clinical application.EMBO molecular medicine · 2022Review
- Association of Energy and Macronutrients Intake with S-Klotho Plasma Levels in Middle-Aged Sedentary Adults: A Cross-Sectional Study.The journal of nutrition, health & aging · 2022Article
- Protein-to-carbohydrate ratio is informative of diet quality and associates with all-cause mortality: Findings from the National Health and Nutrition Examination Survey (2007-2014).Frontiers in public health · 2022Article
- Article
- Editorial: Dietary Strategies for Healthy Aging-Caloric Restriction and Beyond.Frontiers in nutrition · 2022Article
- Purinergic signaling in tanycytes and its contribution to nutritional sensing.Purinergic signalling · 2021Review
- Review
- Molecular and cellular pathways contributing to brain aging.Behavioral and brain functions : BBF · 2021Review
- Regulation of GH and GH Signaling by Nutrients.Cells · 2021Review
- Associations of Plasma Folate and Vitamin B6 With Blood DNA Methylation Age: An Analysis of One-Carbon Metabolites in the VA Normative Aging Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Short-term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue.The FEBS journal · 2021Article
- A glucose-supplemented diet enhances gut barrier integrity inBiology open · 2021Article
- Biological Prescience: The Role of Anticipation in Organismal Processes.Frontiers in physiology · 2021Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Samantha M Solon-BietCharles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia samantha.solon-biet@sydney.edu.au.
Sarah J MitchellCharles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia.
Rafael de CaboCharles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia.
David RaubenheimerCharles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia.
David G Le CouteurCharles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia.
Stephen J SimpsonCharles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia.
Funding
Aging Intervention ProgramZIAAG000363 · NIA · NATIONAL INSTITUTE ON AGING · PI DE CABO, RAFAEL · 2009 to 2025
$9.0MIntramural NIH HHS Z99 AG999999
Abstract
Both lifespan and healthspan are influenced by nutrition, with nutritional interventions proving to be robust across a wide range of species. However, the relationship between nutrition, health and aging is still not fully understood. Caloric restriction is the most studied dietary intervention known to extend life in many organisms, but recently the balance of macronutrients has been shown to play a critical role. In this review, we discuss the current understanding regarding the impact of calories and macronutrient balance in mammalian health and longevity, and highlight the key nutrient-sensing pathways that mediate the effects of nutrition on health and ageing.
Indexed as
AgingAMP-Activated Protein KinasesAnimalsCaloric RestrictionDiet, Protein-RestrictedEnergy IntakeFibroblast Growth FactorsFoodHumansInsulinInsulin-Like Growth Factor ILongevityNutritional Physiological PhenomenaSirtuin 1TOR Serine-Threonine KinasesAMP-Activated Protein Kinasesfibroblast growth factor 21Fibroblast Growth FactorsInsulinInsulin-Like Growth Factor ISirtuin 1TOR Serine-Threonine Kinasescalorieshealthlifespanlongevitymacronutrients
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.