ArticleJournal of abnormal child psychology2016
The Genetic Overlap of Attention-Deficit/Hyperactivity Disorder and Autistic-like Traits: an Investigation of Individual Symptom Scales and Cognitive markers.
Article in Journal of abnormal child psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Medicaid Expansion and Medication Use Among U.S. Children with ASD or ADHD: A Repeated Cross-Sectional Analysis Comparing Before and During the COVID-19 Periods.Healthcare (Basel, Switzerland) · 2026Article
- Neurodevelopmental and Psychosocial Outcomes in Adolescence of Children with Early Diagnoses of ADHD, Autism, Dyscalculia and Dyslexia.Research on child and adolescent psychopathology · 2025Article
- Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder.Nature genetics · 2024Article
- The association between autistic-like traits and sluggish cognitive tempo symptoms in children with ADHD.International journal of developmental disabilities · 2024Article
- Pragmatic language and associations with externalizing behaviors in autistic individuals and those who have lost the autism diagnosis.Research in autism spectrum disorders · 2023Article
- Unique prediction of developmental psychopathology from genetic and familial risk.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Attention/Deficit Hyperactivity Disorder in Adolescent and Young Adult Males With Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2022Article
- ASD with ADHD vs. ASD and ADHD alone: a study of the QbTest performance and single-dose methylphenidate responding in children and adolescents.BMC psychiatry · 2022Article
- Behavioural Measures of Infant Activity but Not Attention Associate with Later Preschool ADHD Traits.Brain sciences · 2021Article
- Latent Structure of Combined Autistic and ADHD Symptoms in Clinical and General Population Samples: A Scoping Review.Frontiers in psychiatry · 2021Article
- An executive functioning perspective in neurofibromatosis type 1: from ADHD and autism spectrum disorder to research domains.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study.BMC neuroscience · 2020Article
- Delineating and validating higher-order dimensions of psychopathology in the Adolescent Brain Cognitive Development (ABCD) study.Translational psychiatry · 2019Article
- A preliminary investigation of reaction time variability in relation to social functioning in children evaluated for ADHD.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2019Article
- Genetic and environmental contribution to the overlap between ADHD and ASD trait dimensions in young adults: a twin study.Psychological medicine · 2019Article
- Ex-Gaussian, Frequency and Reward Analyses Reveal Specificity of Reaction Time Fluctuations to ADHD and Not Autism Traits.Journal of abnormal child psychology · 2019Article
- An emotion recognition subtyping approach to studying the heterogeneity and comorbidity of autism spectrum disorders and attention-deficit/hyperactivity disorder.Journal of neurodevelopmental disorders · 2018Article
- ADHD in children and youth: Part 3-Assessment and treatment with comorbid ASD, ID, or prematurity.Paediatrics & child health · 2018Review
- Structural brain imaging correlates of ASD and ADHD across the lifespan: a hypothesis-generating review on developmental ASD-ADHD subtypes.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- Response time variability under slow and fast-incentive conditions in children with ASD, ADHD and ASD+ADHD.Journal of child psychology and psychiatry, and allied disciplines · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs) frequently co-occur. However, due to previous exclusionary diagnostic criteria, little is known about the underlying causes of this covariation. Twin studies assessing ADHD symptoms and autistic-like traits (ALTs) suggest substantial genetic overlap, but have largely failed to take into account the genetic heterogeneity of symptom subscales. This study aimed to clarify the phenotypic and genetic relations between ADHD and ASD by distinguishing between symptom subscales that characterise the two disorders. Moreover, we aimed to investigate whether ADHD-related cognitive impairments show a relationship with ALT symptom subscales; and whether potential shared cognitive impairments underlie the genetic risk shared between the ADHD and ALT symptoms. Multivariate structural equation modelling was conducted on a population-based sample of 1312 twins aged 7-10. Social-communication ALTs correlated moderately with both ADHD symptom domains (phenotypic correlations around 0.30) and showed substantial genetic overlap with both inattention and hyperactivity-impulsivity (genetic correlation = 0.52 and 0.44, respectively). In addition to previously reported associations with ADHD traits, reaction time variability (RTV) showed significant phenotypic (0.18) and genetic (0.32) association with social-communication ALTs. RTV captured a significant proportion (24 %) of the genetic influences shared between inattention and social-communication ALTs. Our findings suggest that social-communication ALTs underlie the previously observed phenotypic and genetic covariation between ALTs and ADHD symptoms. RTV is not specific to ADHD symptoms, but is also associated with social-communication ALTs and can, in part, contribute to an explanation of the co-occurrence of ASD and ADHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.