ArticleIET systems biology2015
Synthesising gene clock with toggle switch and oscillator.
Article in IET systems biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Synthesis of control unit for future biocomputer.Journal of biological engineering · 2018Article
- Delay decomposition approach to [Formula: see text] filtering analysis of genetic oscillator networks with time-varying delays.Cognitive neurodynamics · 2016Article
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3 authors.
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Abstract
The usefulness of a genetic clock lies in its role to stimulate a sequence of logic reactions for sequential biological circuits. A clock signal is a periodic square wave, its amplitude alternates at a steady frequency between fixed minimal and maximal levels. Transition between the minimum and the maximum is instantaneous for an ideal square wave; however, the function is unrealisable in physical bio-systems. This research develops a new genetic clock generator based on a genetic oscillator, in which, a sine wave generator is adopted as a signal oscillator. It is shown that combination of a genetic oscillator with a toggle switch is able to generate clock signals forming an efficient way to generate a near square wave. In silico study confirms the proposed idea.
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