ArticlePloS one2015
Parallel changes in structural and functional measures of optic nerve myelination after optic neuritis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Structure-function relationship between handheld photopic negative response and macular GCIPL thickness in chronic optic neuropathy.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Timing matters when using paraclinical tests to assess for optic neuritis under the 2024 McDonald criteria.BMJ neurology open · 2026Article
- Vitamin B12 Levels Association with Functional and Structural Biomarkers of Central Nervous System Injury in Older Adults.Annals of neurology · 2025Article
- Visual outcome measures in clinical trials of remyelinating drugs.BMJ neurology open · 2024Review
- Visual Evoked Potentials for the Detection of Diabetic Retinal Neuropathy.International journal of molecular sciences · 2023Review
- Long-term Effect of Permanent Demyelination on Axonal Survival in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2022Article
- [Optic neuritis: aetiopathogenesis, diagnosis, prognosis and management].Revista de neurologia · 2022Review
- Analysis of Multifocal Visual Evoked Potentials Using Artificial Intelligence Algorithms.Translational vision science & technology · 2022Article
- Therapeutic potential of human umbilical cord-derived mesenchymal stem cells transplantation in rats with optic nerve injury.Indian journal of ophthalmology · 2022Article
- Differences in the involved sites among different types of demyelinating optic neuritis in traditional MRI examination: A systematic review and meta-analysis.Advances in ophthalmology practice and research · 2021Review
- Role of Multifocal Visually Evoked Potential as a Biomarker of Demyelination, Spontaneous Remyelination, and Myelin Repair in Multiple Sclerosis.Frontiers in neuroscience · 2021Review
- Chronic demyelination exacerbates neuroaxonal loss in patients with MS with unilateral optic neuritis.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Using the Anterior Visual System to Assess Neuroprotection and Remyelination in Multiple Sclerosis Trials.Current neurology and neuroscience reports · 2018Review
- Using Deep Learning for the Classification of Images Generated by Multifocal Visual Evoked Potential.Frontiers in neurology · 2018Article
- Empirical mode decomposition processing to improve multifocal-visual-evoked-potential signal analysis in multiple sclerosis.PloS one · 2018Article
- A Study of the Correlation between VEP and Clinical Severity in Children with Autism Spectrum Disorder.Autism research and treatment · 2018Article
- The signal intensity ratio of the optic nerve to ipsilateral frontal white matter is of value in the diagnosis of acute optic neuritis.European radiology · 2016Article
- Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis.Journal of ophthalmology · 2016Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVisual evoked potential (VEP) latency prolongation and optic nerve lesion length after acute optic neuritis (ON) corresponds to the degree of demyelination, while subsequent recovery of latency may represent optic nerve remyelination. We aimed to investigate the relationship between multifocal VEP (mfVEP) latency and optic nerve lesion length after acute ON.
methodsThirty acute ON patients were studied at 1, 3, 6 and 12 months using mfVEP and at 1 and 12 months with optic nerve MRI. LogMAR and low contrast visual acuity were documented. By one month, the mfVEP amplitude had recovered sufficiently for latency to be measured in 23 (76.7%) patients with seven patients having no recordable mfVEP in more than 66% of segments in at least one test. Only data from these 23 patients was analysed further.
resultsBoth latency and lesion length showed significant recovery during the follow-up period. Lesion length and mfVEP latency were highly correlated at 1 (r = 0.94, p = <0.0001) and 12 months (r = 0.75, p < 0.001). Both measures demonstrated a similar trend of recovery. Speed of latency recovery was faster in the early follow-up period while lesion length shortening remained relatively constant. At 1 month, latency delay was worse by 1.76 ms for additional 1mm of lesion length while at 12 months, 1mm of lesion length accounted for 1.94 ms of latency delay.
conclusionA strong association between two putative measures of demyelination in early and chronic ON was found. Parallel recovery of both measures could reflect optic nerve remyelination.
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