ArticlePloS one2015
Candidatus Frankia Datiscae Dg1, the Actinobacterial Microsymbiont of Datisca glomerata, Expresses the Canonical nod Genes nodABC in Symbiosis with Its Host Plant.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 112 citations in OpenAlex.
- Integrated multi-omics decipher the complex nodule microbiota and distinct Frankiaceae symbiotic traits in wild actinorhizal plants.The New phytologist · 2026Article
- Convergent evolution ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Host-dependent specialized metabolism of nitrogen export in actinorhizal nodules induced by diazotrophic Actinomycetota Frankia cluster-2.Journal of experimental botany · 2025Article
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- Comparative metagenomics of wild and cultivatedCurrent research in microbial sciences · 2025Article
- Deciphering Molecular Mechanisms and Diversity of Plant Holobiont Bacteria: Microhabitats, Community Ecology, and Nutrient Acquisition.International journal of molecular sciences · 2024Review
- Frankia [NiFe] uptake hydrogenases and genome reduction: different lineages of loss.FEMS microbiology ecology · 2024Article
- Genome analysis and biogeographic distribution of the earliest divergent Frankia clade in the southern hemisphere.FEMS microbiology ecology · 2024Article
- MAGs-centric crack: how long will, spore-positiveFrontiers in microbiology · 2024Article
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- Genomic Insights ofGenes · 2023Article
- Review
- NADMicrobes and environments · 2023Article
- Draft Genomes ofJournal of genomics · 2023Article
- A tale of two lineages: how the strains of the earliest divergent symbiotic Frankia clade spread over the world.BMC genomics · 2022Article
- Pseudogenization of the rhizobium-responsive EXOPOLYSACCHARIDE RECEPTOR in Parasponia is a rare event in nodulating plants.BMC plant biology · 2022Article
- The Proteogenome of SymbioticMicroorganisms · 2022Article
- Legume NCRs and nodule-specific defensins of actinorhizal plants-Do they share a common origin?PloS one · 2022Article
- Draft Genomes of Nitrogen-fixingJournal of genomics · 2022Article
- Microevolution, speciation and macroevolution in rhizobia: Genomic mechanisms and selective patterns.Frontiers in plant science · 2022Review
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Authors and funding
16 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frankia strains are nitrogen-fixing soil actinobacteria that can form root symbioses with actinorhizal plants. Phylogenetically, symbiotic frankiae can be divided into three clusters, and this division also corresponds to host specificity groups. The strains of cluster II which form symbioses with actinorhizal Rosales and Cucurbitales, thus displaying a broad host range, show suprisingly low genetic diversity and to date can not be cultured. The genome of the first representative of this cluster, Candidatus Frankia datiscae Dg1 (Dg1), a microsymbiont of Datisca glomerata, was recently sequenced. A phylogenetic analysis of 50 different housekeeping genes of Dg1 and three published Frankia genomes showed that cluster II is basal among the symbiotic Frankia clusters. Detailed analysis showed that nodules of D. glomerata, independent of the origin of the inoculum, contain several closely related cluster II Frankia operational taxonomic units. Actinorhizal plants and legumes both belong to the nitrogen-fixing plant clade, and bacterial signaling in both groups involves the common symbiotic pathway also used by arbuscular mycorrhizal fungi. However, so far, no molecules resembling rhizobial Nod factors could be isolated from Frankia cultures. Alone among Frankia genomes available to date, the genome of Dg1 contains the canonical nod genes nodA, nodB and nodC known from rhizobia, and these genes are arranged in two operons which are expressed in D. glomerata nodules. Furthermore, Frankia Dg1 nodC was able to partially complement a Rhizobium leguminosarum A34 nodC::Tn5 mutant. Phylogenetic analysis showed that Dg1 Nod proteins are positioned at the root of both α- and β-rhizobial NodABC proteins. NodA-like acyl transferases were found across the phylum Actinobacteria, but among Proteobacteria only in nodulators. Taken together, our evidence indicates an Actinobacterial origin of rhizobial Nod factors.
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