ArticlePLoS genetics2015
A Simple Auxin Transcriptional Response System Regulates Multiple Morphogenetic Processes in the Liverwort Marchantia polymorpha.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed, 205 citations in OpenAlex.
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- A key role for S-nitrosylation in immune regulation and development in the liverwort Marchantia polymorpha.Journal of experimental botany · 2026Article
- 800 million years of co-evolution in the green plant lineage: the case of LEUNIG and SEUSS transcriptional co-regulators.Molecular biology and evolution · 2026Article
- Laser ablation microscopy reveals apical notch, apical dominance, and meristem regeneration dynamics inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Complete loss of A-ARF activity in bryophytes reveals a role for auxin-adjacent regulatory networks.Journal of experimental botany · 2025Article
- The role of auxin-mediated gene activation in the bryophyte, Physcomitrium patens.Journal of experimental botany · 2025Article
- The role of indole-3-acetic acid and characterization of PIN transporters in complex streptophyte alga Chara braunii.The New phytologist · 2025Article
- Tissue-Specific Differential Distribution of Cell Wall Epitopes inInternational journal of molecular sciences · 2025Article
- The Expansion and Diversification of Epigenetic Regulatory Networks Underpins Major Transitions in the Evolution of Land Plants.Molecular biology and evolution · 2025Article
- Identification and characterization of DICER-LIKE genes and their roles in Marchantia polymorpha development and salt stress response.The Plant journal : for cell and molecular biology · 2025Article
- Three-dimensional anatomy and dorsoventral asymmetry of the mature Marchantia polymorpha meristem develops from a symmetrical gemma meristem.Development (Cambridge, England) · 2024Article
- Quantitative imaging reveals the role of MpARF proteasomal degradation during gemma germination.Plant communications · 2024Article
- Analysis of auxin responses in the fern Ceratopteris richardii identifies the developmental phase as a major determinant for response properties.Development (Cambridge, England) · 2024Article
- Article
- Harnessing Deep Learning to Analyze Cryptic Morphological Variability of Marchantia polymorpha.Plant & cell physiology · 2023Article
- To bind or not to bind: how AUXIN RESPONSE FACTORs select their target genes.Journal of experimental botany · 2023Review
- Auxins and grass shoot architecture: how the most important hormone makes the most important plants.Journal of experimental botany · 2023Review
- Game of thrones among AUXIN RESPONSE FACTORs-over 30 years of MONOPTEROS research.Journal of experimental botany · 2023Review
- An enhancer trap system to track developmental dynamics in Marchantia polymorpha.The Plant journal : for cell and molecular biology · 2023Article
- The TOPLESS corepressor regulates developmental switches in the bryophyte Physcomitrium patens that were critical for plant terrestrialisation.The Plant journal : for cell and molecular biology · 2023Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In land plants comparative genomics has revealed that members of basal lineages share a common set of transcription factors with the derived flowering plants, despite sharing few homologous structures. The plant hormone auxin has been implicated in many facets of development in both basal and derived lineages of land plants. We functionally characterized the auxin transcriptional response machinery in the liverwort Marchantia polymorpha, a member of the basal lineage of extant land plants. All components known from flowering plant systems are present in M. polymorpha, but they exist as single orthologs: a single MpTOPLESS (TPL) corepressor, a single MpTRANSPORT inhibitor response 1 auxin receptor, single orthologs of each class of auxin response factor (ARF; MpARF1, MpARF2, MpARF3), and a single negative regulator auxin/indole-3-acetic acid (MpIAA). Phylogenetic analyses suggest this simple system is the ancestral condition for land plants. We experimentally demonstrate that these genes act in an auxin response pathway--chimeric fusions of the MpTPL corepressor with heterodimerization domains of MpARF1, MpARF2, or their negative regulator, MpIAA, generate auxin insensitive plants that lack the capacity to pattern and transition into mature stages of development. Our results indicate auxin mediated transcriptional regulation acts as a facilitator of branching, differentiation and growth, rather than acting to determine or specify tissues during the haploid stage of the M. polymorpha life cycle. We hypothesize that the ancestral role of auxin is to modulate a balance of differentiated and pluri- or totipotent cell states, whose fates are determined by interactions with combinations of unrelated transcription factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.