Trial reportPloS one2015
Radiological findings in young children investigated for tuberculosis in Mozambique.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Tuberculosis and HIV Coinfection Admissions and Outcome in Children at a Nigerian Tertiary Hospital.Annals of African medicine · 2026Article
- Evaluation of the Performance of Stool Samples to Diagnose Pediatric Pulmonary Tuberculosis in Routine Care: A Cohort Study From Pakistan.Open forum infectious diseases · 2025Article
- Multi-view deep learning framework for the detection of chest X-rays compatible with pediatric pulmonary tuberculosis.Nature communications · 2025Article
- Clinical and radiological profile of tuberculosis and treatment outcome in patients ≤18 years: A prospective study.Journal of family medicine and primary care · 2025Article
- Oral Swab Testing With Xpert MTB/RIF Ultra for the Diagnosis of Tuberculosis in Children Aged <5 Years in Uganda: An Exploratory Interim Analysis of Diagnostic Accuracy in the NOD-pedFEND Cohort.Open forum infectious diseases · 2025Article
- Diagnostic performance of chest radiography for pediatric tuberculosis across high- and low-burden settings.Frontiers in pediatrics · 2025Article
- Accuracy of CAD4TB (Computer-Aided Detection for Tuberculosis) on paediatric chest radiographs.The European respiratory journal · 2024Article
- External quality assurance of chest X-ray interpretation to strengthen diagnosis of childhood TB.IJTLD open · 2024Article
- Chest X-Ray-Based Telemedicine Platform for Pediatric Tuberculosis Diagnosis in Low-Resource Settings: Development and Validation Study.JMIR pediatrics and parenting · 2024Article
- Comparison of chest ultrasound features to chest radiography in the diagnosis for pediatric tuberculosis: a cross-sectional study.The Pan African medical journal · 2024Article
- Multidrug-Resistant TB (MDR-TB) and Extensively Drug-Resistant TB (XDR-TB) Among Children: Where We Stand Now.Cureus · 2023Review
- Xpert MTB/RIF Ultra and mycobacterial culture in routine clinical care at a paediatric hospital.Southern African journal of infectious diseases · 2022Article
- Diagnosis and management of community-acquired pneumonia in children: South African Thoracic Society guidelines.African journal of thoracic and critical care medicine · 2020Article
- Chest ultrasound compared to chest X-ray for pediatric pulmonary tuberculosis.Pediatric pulmonology · 2019Article
- Knowledge, attitudes and practices regarding tuberculosis care among health workers in Southern Mozambique.BMC pulmonary medicine · 2017Article
- High Rates of Non-Tuberculous Mycobacteria Isolation in Mozambican Children with Presumptive Tuberculosis.PloS one · 2017Article
- Correction: Radiological Findings in Young Children Investigated for Tuberculosis in Mozambique.PloS one · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChest radiography remains a critical tool for diagnosing intrathoracic tuberculosis (TB) in young children who are unable to expectorate. We describe the radiological findings in children under 3 years of age investigated for TB in the district of Manhiça, southern Mozambique, an area with a high prevalence of TB and HIV.
methodsDigital antero-posterior and lateral projections were performed and reviewed by two independent readers, using a standardized template. Readers included a local pediatrician and a pediatric radiologist blinded to all clinical information. International consensus case definitions for intra-thoracic TB in children were applied.
resultsA total of 766 children were evaluated of whom 43 (5.6%) had TB. The most frequent lesion found in TB cases was air space consolidation (65.1%), followed by suggestive hilar lymphadenopathy (17.1%) and pleural effusion (7.0%). Air space consolidation was significantly more common in TB cases than in non-TB cases (odds ratio 8.9; 95% CI: 1.6-50.5), as were hilar lymphadenopathy (OR 17.2; 95% CI: 5.7-52.1). The only case with miliary infiltrates and 3 with pleural effusions occurred in HIV-infected children.
conclusionFrequent air space consolidation complicates radiological distinction between TB and bacterial pneumonia in young children, underscoring the need for epidemiological contextualization and consideration of all relevant signs and symptoms.
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