ArticleRadiology2015
In Vivo Quantitative MR Imaging of Bound and Pore Water in Cortical Bone.
Article in Radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 71 citations in OpenAlex.
- Inverting CEST orMagnetic resonance in medicine · 2026Article
- UTE MRI technical developments and applications in osteoporosis: a review.Frontiers in endocrinology · 2025Review
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- Ultrashort echo time MRI detects significantly lower collagen but higher pore water in the tibial cortex of female patients with osteopenia and osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Bone Biomarkers Based on Magnetic Resonance Imaging.Seminars in musculoskeletal radiology · 2024Review
- In Vivo Assessment of Bone Quality Without X-rays.Current osteoporosis reports · 2024Review
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- Comprehensive assessment of osteoporosis in lumbar spine using compositional MR imaging of trabecular bone.European radiology · 2023Article
- TNMR in biomedicine · 2023Article
- MRI Quantification of Cortical Bone Porosity, Mineralization, and Morphologic Structure in Postmenopausal Osteoporosis.Radiology · 2023Article
- Fast bound and pore water mapping of cortical bone with arbitrary slice oriented two-dimensional ultra-short echo time.Magnetic resonance in medicine · 2023Article
- Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target?Bone reports · 2022Article
- MRI-based mechanical competence assessment of bone using micro finite element analysis (micro-FEA): Review.Magnetic resonance imaging · 2022Review
- High-contrast osteochondral junction imaging using a 3D dual adiabatic inversion recovery-prepared ultrashort echo time cones sequence.NMR in biomedicine · 2021Article
- Survey of MRI Usefulness for the Clinical Assessment of Bone Microstructure.International journal of molecular sciences · 2021Review
- Article
- Impact of gradient imperfections on bone water quantification with UTE MRI.Magnetic resonance in medicine · 2020Article
- Water proton density in human cortical bone obtained from ultrashort echo time (UTE) MRI predicts bone microstructural properties.Magnetic resonance imaging · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo translate and evaluate an in vivo magnetic resonance (MR) imaging protocol for quantitative mapping of collagen-bound and pore water concentrations in cortical bone that involves relaxation-selective ultrashort echo time (UTE) methods. MATERIALS AND
methodsAll HIPAA-compliant studies were performed with institutional review board approval and written informed consent. UTE imaging sequences were implemented on a clinical 3.0-T MR imaging unit and were used for in vivo imaging of bound and pore water in cortical bone. Images of the lower leg and wrist were acquired in five volunteers each (lower leg: two men and three women aged 24, 24, 49, 30, and 26 years; wrist: two men and three women aged 31, 23, 25, 24, and 26 years) to generate bound and pore water concentration maps of the tibia and radius. Each volunteer was imaged three times, and the standard error of the measurements at the region-of-interest (ROI) level was computed as the standard deviation across studies, pooled across volunteers and ROIs.
resultsQuantitative bound and pore water maps in the tibia and radius, acquired in 8-14 minutes, had per-voxel signal-to-noise ratios of 18 (bound water) and 14 (pore water) and inter-study standard errors of approximately 2 mol (1)H per liter of bone at the ROI level.
conclusionThe results of this study demonstrate the feasibility of quantitatively mapping bound and pore water in vivo in human cortical bone with practical human MR imaging constraints.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.