ArticleJournal of the American Chemical Society2015
Protein-induced supramolecular disassembly of amphiphilic polypeptide nanoassemblies.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Stepwise disassembly of supramolecular structures triggered by specific protein binding.Biophysical journal · 2026Article
- Structural Determinants of Stimuli-Responsiveness in Amphiphilic Macromolecular Nano-assemblies.Progress in polymer science · 2024Article
- Therapeutic Supramolecular Polymers: Designs and Applications.Progress in polymer science · 2024Article
- Albumin-mediated "Unlocking" of supramolecular prodrug-like nanozymes toward selective imaging-guided phototherapy.Chemical science · 2022Article
- Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-RSC advances · 2021Article
- Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks.Biomacromolecules · 2021Article
- Supramolecular antibiotics: a strategy for conversion of broad-spectrum to narrow-spectrum antibiotics forNanoscale · 2020Article
- Target-driven supramolecular self-assembly for selective amyloid-β photooxygenation against Alzheimer's disease.Chemical science · 2020Article
- An Azobenzene-Based Single-Component Supramolecular Polymer Responsive to Multiple Stimuli in Water.Journal of the American Chemical Society · 2020Article
- Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor.Molecular therapy. Methods & clinical development · 2019Review
- Supramolecular catalysis and dynamic assemblies for medicine.Chemical Society reviews · 2017Review
- Using Dynamic Covalent Chemistry To Drive Morphological Transitions: Controlled Release of Encapsulated Nanoparticles from Block Copolymer Vesicles.Journal of the American Chemical Society · 2017Article
- Programmable Nanoassemblies from Non-Assembling Homopolymers Using Ad Hoc Electrostatic Interactions.Angewandte Chemie (International ed. in English) · 2017Article
- In Vivo Efficacy of Measles Virus Fusion Protein-Derived Peptides Is Modulated by the Properties of Self-Assembly and Membrane Residence.Journal of virology · 2017Article
- Multi-Stimuli-Responsive Amphiphilic Assemblies through Simple Postpolymerization Modifications.Macromolecules · 2016Article
- Smart Organic Two-Dimensional Materials Based on a Rational Combination of Non-covalent Interactions.Angewandte Chemie (International ed. in English) · 2016Article
- Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems.Chemical Society reviews · 2016Review
- HChemical science · 2016Article
- Progress in material design for biomedical applications.Proceedings of the National Academy of Sciences of the United States of America · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mimicking noncovalent interaction based processes in nature has been an important goal of supramolecular chemistry. Here, we report on amphiphilic polypeptides that self-assemble to form nanoscale supramolecular assemblies and are programmed to disassemble in response to a specific protein. Benzenesulfonamide and carbonic anhydrase have been chosen as the ligand and protein, respectively, to demonstrate this possibility. Since the amphiphilic nanoassembly sequesters hydrophobic guest molecules, the protein-specific disassembly event provides a protein-sensitive molecular release as well. We envision that the binding induced disassembly and guest release might open up new opportunities for the next generation of supramolecular assemblies for protein-specific delivery and diagnostics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.