ReviewChest2015
Putative Links Between Sleep Apnea and Cancer: From Hypotheses to Evolving Evidence.
Review in Chest, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- CPAP to Reduce the Risk of Cancer in OSA?-A Meta-Analysis of 3 RCTs.Journal of sleep research · 2026Pooled it
- Does CPAP increase or protect against cancer risk in OSA: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2025Pooled it
- Review
- Is obstructive sleep apnea a driver of cancer and chronic disease risk? A real-world analysis of over 3 million patients.BMC pulmonary medicine · 2026Article
- [Research Advances in Obstructive Sleep Apnea and Lung Cancer Comorbidity].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026Review
- The vicious cycle of circadian disruption and obstructive sleep apnea: implications for cancer risk.Journal of the National Cancer Center · 2026Article
- Research status and progress on the relationship between obstructive sleep apnea and pulmonary nodules.Frontiers in medicine · 2026Review
- Obstructive sleep apnea and lung cancer: molecular underpinnings and clinical translational prospects.Frontiers in cell and developmental biology · 2026Review
- Cancer and obstructive sleep apnea.Chinese medical journal · 2025Article
- Recent advances in the study of the correlation between obstructive sleep apnea and thyroid-disorders.Sleep & breathing = Schlaf & Atmung · 2025Review
- Association of obstructive sleep apnea with risk of lung cancer: a nationwide cohort study in Korea.Scientific reports · 2024Article
- Sleep disorders and cancer incidence: examining duration and severity of diagnosis among veterans.Frontiers in oncology · 2024Article
- Evaluation of obstructive sleep apnea: an analysis based on aberrant genes.Sleep & breathing = Schlaf & Atmung · 2023Article
- Compensatory mechanisms of reduced interhemispheric EEG connectivity during sleep in patients with apnea.Scientific reports · 2023Article
- Differential Impact of Intermittent vs. Sustained Hypoxia on HIF-1, VEGF and Proliferation of HepG2 Cells.International journal of molecular sciences · 2023Article
- Association between obstructive sleep apnoea and cancer: a cross-sectional, population-based study of the DISCOVERY cohort.BMJ open · 2023Article
- Cancer-related Fatigue in Lung Cancer: A Research Agenda: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2023Article
- The Impact of Immunotherapy on Sleep and Circadian Rhythms in Patients with Cancer.Frontiers in oncology · 2023Review
- Lung cancer, comorbidities, and medication: the infernal trio.Frontiers in pharmacology · 2023Review
- Sleep Disorders and Quality of Life in Patients With Cancer: Prospective Observational Study of the Rafael Institute.JMIR formative research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
In recent years, the potentially adverse role of sleep-disordered breathing in cancer incidence and outcomes has emerged. In parallel, animal models of intermittent hypoxia (IH) and sleep fragmentation (SF) emulating the two major components of OSA have lent support to the notion that OSA may enhance the proliferative and invasive properties of solid tumors. Based on several lines of evidence, we propose that OSA-induced increases in sympathetic outflow and alterations in immune function are critically involved in modifying oncologic processes including angiogenesis. In this context, we suggest that OSA, via IH (and potentially SF), promotes changes in several signaling pathways and transcription factors that coordinate malignant transformation and expansion, disrupts host immunologic surveillance, and consequently leads to increased probability of oncogenesis, accelerated tumor proliferation, and invasion, ultimately resulting in adverse outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.