Evidence map›Paper›PMID 26020048›Full record

ArticleEndoscopic ultrasound

Role of endoscopic ultrasound-guided fine needle aspiration and ultrasound-guided fine-needle aspiration in diagnosis of cystic pancreatic lesions.

Hussein Hassan Okasha, Mahmoud Ashry, Hala M K Imam, Reem Ezzat, Mohamed Naguib, Ali H Farag, Emad H Gemeie, Hani M Khattab

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endoscopic ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Imaging modalities for characterising focal pancreatic lesions.The Cochrane database of systematic reviews · 2017
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Cystic pancreatic lesions, the endless dilemma.World journal of gastroenterology · 2021
    Article
  6. Article
  7. Diagnostic and therapeutic biomarkers in pancreaticobiliary malignancy.World journal of gastrointestinal endoscopy · 2016
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hussein Hassan OkashaDepartment of Internal Medicine, Cairo University, Oula, Giza, Egypt.
Mahmoud AshryDepartment of Internal Medicine, Assiut University, Assiut, Egypt.
Hala M K ImamDepartment of Internal Medicine, Assiut University, Assiut, Egypt.
Reem EzzatDepartment of Internal Medicine, Assiut University, Assiut, Egypt.
Mohamed NaguibDepartment of Internal Medicine, Cairo University, Oula, Giza, Egypt.
Ali H FaragDepartment of Internal Medicine, Cairo University, Oula, Giza, Egypt.
Emad H GemeieDepartment of Pathology, National Cancer Institute, Oula, Giza, Egypt.
Hani M KhattabDepartment of Pathology, Cairo University, Oula, Giza, Egypt.
Cairo University · EGAssiut University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe addition of fine-needle aspiration (FNA) to different imaging modalities has raised the accuracy for diagnosis of cystic pancreatic lesions. We aim to differentiate benign from neoplastic pancreatic cysts by evaluating cyst fluid carcinoembryonic antigen (CEA), carbohydrate antigen (CA19-9), and amylase levels and cytopathological examination, including mucin stain. PATIENTS AND

methodsThis prospective study included 77 patients with pancreatic cystic lesions. Ultrasound-FNA (US-FNA) or endoscopic ultrasound-FNA (EUS-FNA) was done according to the accessibility of the lesion. The aspirated specimens were subjected to cytopathological examination (including mucin staining), tumor markers (CEA, CA19-9), and amylase level.

resultsCyst CEA value of 279 or more showed high statistical significance in differentiating mucinous from nonmucinous lesions with sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of 73%, 60%, 50%, 80%, and 65%, respectively. Cyst amylase could differentiate between neoplastic and nonneoplastic cysts at a level of 1043 with sensitivity of 58%, specificity of 75%, PPV of 73%, NPV of 60%, and accuracy of 66%. CA19-9 could not differentiate between neoplastic and nonneoplastic cysts. Mucin examination showed a sensitivity of 85%, specificity of 95%, PPV of 92%, NPV of 91%, and accuracy of 91% in differentiating mucinous from non-mucinous lesions. Cytopathological examination showed a sensitivity of 81%, specificity of 94%, PPV of 94%, NPV of 83%, and accuracy of 88%.

conclusionUS or EUS-FNA with analysis of cyst CEA level, CA19-9, amylase, mucin stain, and cytopathological examination increases the diagnostic accuracy of cystic pancreatic lesions.

Indexed as

Cystic lesiondiagnosisendoscopic ultrasoundfine needle aspirationpancreatic lesionultrasound

Identifiers

PMID26020048
PMCPMC4445171
OpenAlexW1582513133

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.