ArticleIranian journal of basic medical sciences2015
Neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia.
Article in Iranian journal of basic medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 66 citations in OpenAlex.
- Natural Phenolic Compounds with Neuroprotective Effects.Neurochemical research · 2024Review
- P-coumaric Acid: Advances in Pharmacological Research Based on Oxidative Stress.Current topics in medicinal chemistry · 2024Review
- Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids.Molecules (Basel, Switzerland) · 2023Review
- A Review on Polyphenols inNutrients · 2023Review
- Non-Enzymatic Antioxidants against Alzheimer's Disease: Prevention, Diagnosis and Therapy.Antioxidants (Basel, Switzerland) · 2023Review
- Polyphenols and Their Nanoformulations: Protective Effects against Human Diseases.Life (Basel, Switzerland) · 2022Review
- p-Coumaric acid protects against D-galactose induced neurotoxicity by attenuating neuroinflammation and apoptosis in mice brain.Metabolic brain disease · 2022Article
- Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer's Disease.Nutrients · 2022Review
- Development ofJournal of clinical medicine · 2020Article
- From Preclinical Stroke Models to Humans: Polyphenols in the Prevention and Treatment of Stroke.Nutrients · 2020Review
- Polyphenols and Other Bioactive Compounds ofMolecules (Basel, Switzerland) · 2020Review
- Neuroprotective potential of Myrciaria plinioides D. Legrand extract in an in vitro human neuroblastoma model.Inflammopharmacology · 2020Article
- Article
- Bioactive Compounds, Antioxidant Activity and Inhibition of Key Enzymes Relevant to Alzheimer's Disease from Sweet Pepper (Preventive nutrition and food science · 2019Article
- Nootropic and Anti-Alzheimer's Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer's Neuropathology.Molecular neurobiology · 2019Review
- Capability of polygonum cuspidatum extract in inhibiting AGEs and preventing diabetes.Food science & nutrition · 2019Article
- Antidepressant-like Effects of p-Coumaric Acid on LPS-induced Depressive and Inflammatory Changes in Rats.Experimental neurobiology · 2018Article
- Neuroprotective effect of p-coumaric acid in mice with cerebral ischemia reperfusion injuries.Metabolic brain disease · 2018Article
- Gallic acid and p-coumaric acid attenuate type 2 diabetes-induced neurodegeneration in rats.Metabolic brain disease · 2017Article
- Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesStroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. MATERIAL AND
methodsRats were randomly divided into four groups, namely Group I (control rats), Group II (ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). Cerebral ischemia was induced via intraluminal monofilament occlusion model. In all groups, the brain was removed after the procedure and rats were sacrificed. Malondialdehyde, superoxide dismutase and nuclear respiratory factor-1 were measured in the ischemic hemisphere. The histopathological changes were observed in the right hemisphere within the samples. Functional assessment was performed for neurological deficit scores.
resultsFollowing the treatment, biochemical factors changed significantly. Histopathologically, it was shown that p-coumaric acid decreased the oxidative damage. The neurological deficit scores of p-coumaric acid-treated rats were significantly improved after cerebral ischemia.
conclusionOur results showed that p-coumaric acid is a neuroprotective agent on account of its strong anti-oxidant and anti-apoptotic features. Moreover, p-coumaric acid decreased the focal ischemia. Extra effort should be made to introduce p-coumaric acid as a promising therapeutic agent to be utilized for treatment of human cerebral ischemia in the future.
Indexed as
Identifiers
26019798PMC4439450W1484463033What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.