Evidence map›Paper›PMID 26019778›Full record

ArticleIranian journal of pediatrics2014

Prevalence of Celiac Disease in Children with Autoimmune Hepatitis and vice versa.

Mehri Najafi, Nooshin Sadjadei, Kambiz Eftekhari, Ahmad Khodadad, Farzaneh Motamed, Gholam-Hossain Fallahi, Fatemeh Farahmand

Open access · greenAbstract read
In one paragraph

Article in Iranian journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Celiac disease: Understandings in diagnostic, nutritional, and medicinal aspects.International journal of immunopathology and pharmacology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Mehri NajafiDepartment of Pediatrics, ; Children's Medical Center, Pediatrics Center of Excellence.
Nooshin SadjadeiDepartment of Pediatric, Jondi Shapoor University of Medical Sciences, Ahvaz, Iran.
Kambiz EftekhariDepartment of Pediatrics, ; Bahrami Hospital, Tehran University of Medical Sciences, Tehran.
Ahmad KhodadadDepartment of Pediatrics, ; Children's Medical Center, Pediatrics Center of Excellence.
Farzaneh MotamedDepartment of Pediatrics, ; Children's Medical Center, Pediatrics Center of Excellence.
Gholam-Hossain FallahiDepartment of Pediatrics, ; Children's Medical Center, Pediatrics Center of Excellence.
Fatemeh FarahmandDepartment of Pediatrics, ; Children's Medical Center, Pediatrics Center of Excellence.
Children's Medical Center · IRAhvaz Jundishapur University of Medical Sciences · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCeliac disease is an autoimmune disorder in which the risk of autoimmune liver disease is high. Autoimmune hepatitis is a chronic and progressive entity and the risk of its being associated with other autoimmune disorders such as celiac disease is high also. The aim of this study was to determine the prevalence of celiac disease in patients with autoimmune hepatitis and vice versa.

methodsIn a cross-sectional study children with autoimmune hepatitis underwent serological screening and endoscopy for celiac disease. In patients with celiac disease, serum aminotransferases were measured and, if abnormal, autoantibodies related to autoimmune hepatitis were checked and needle liver biopsy was performed.

findingsOf the 96 patients, 64 had autoimmune hepatitis and 32 celiac disease. Among patients with autoimmune hepatitis only three (4.7%) were compatible with celiac disease. In the group of patients with celiac disease, autoimmune hepatitis was confirmed in four (12.5%) cases. We consider important to state that 3.1% of this group had celiac hepatitis.

conclusionAutoimmune liver disease is sometimes associated with latent celiac disease. Serological screening for celiac disease should be routinely done in patients with abnormal serum aminotransferases, particularly those with chronic liver disease. On the other hand, celiac disease is often accompanied by other autoimmune diseases, including autoimmune hepatitis.

Indexed as

Anti-Nuclear AntibodyAnti Smooth Muscle AntibodyAnti Tissue Transglutaminase Antibody (tTG-IgA)Autoimmune HepatitisCeliac Disease

Identifiers

PMID26019778
PMCPMC4442834
OpenAlexW2166981850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.