ArticleIranian journal of pediatrics2014
Presepsin (scd14) as a marker of serious bacterial infections in chemotherapy induced severe neutropenia.
Article in Iranian journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- Search for novel biomarkers of febrile neutropenia in hematological patients: an overview.Clinical and experimental medicine · 2025Review
- Crossing Age Boundaries: The Unifying Potential of Presepsin in Sepsis Diagnosis Across Diverse Age Groups.Journal of clinical medicine · 2024Review
- The role of presepsin in pediatric patients with oncological and hematological diseases experiencing febrile neutropenia.Scientific reports · 2023Article
- Is There a Role of Presepsin as a Novel Biomarker in Pediatric Sepsis?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- Presepsin as a diagnostic marker of bacterial infections in febrile neutropenic pediatric patients with hematological malignancies.International journal of hematology · 2018Article
- Serum Presepsin Levels Are Not Elevated in Patients with Controlled Hypertension.International journal of hypertension · 2018Article
- Soluble CD14 as a Diagnostic and Prognostic Biomarker in Hematological Patients with Febrile Neutropenia.Disease markers · 2017Article
- Presepsin (sCD14-ST): could it be a novel marker for the diagnosis of ST elevation myocardial infarction?Archives of medical sciences. Atherosclerotic diseases · 2017Article
- Comparison between presepsin, procalcitonin, and CRP as biomarkers to diagnose sepsis in critically ill patients.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTimely detection of serious bacterial infections or prediction of sepsis and death is of paramount importance in neutropenic patients especially in oncology settings. The aim of this study was to determine a rapid and secure predictor of sepsis in severe neutropenic cancer children.
methodsIn addition to blood culture, we have evaluated serum soluble CD14 on this role and measured it in 39 neutropenic episodes in Mahak pediatric oncology center from September 2012 to January 2013. Fifteen episodes had positive bacterial cultures and 18 had fever. The mean sCD14 values were compared in the presence or absence of fever, positive blood culture and other clinical conditions. Also, mean levels compared in different white cell counts and different four combination settings of fever and blood culture.
findingsIt was statistically higher in febrile episodes, in the presence of oral mucositis, indwelling catheter infection, otitis media, and post toxic epidermal necrolysis sepsis and in instances of death within 15 days. Leukocyte count did not affect sCD14 level and in combinations of fever and blood culture, mean sCD14 values were ranked as follow: febrile culture negatives, febrile culture positives, afebrile culture positives and afebrile culture negatives.
conclusionAlthough sCD14 was not sensitive in detection of bacteremia, in the absence of clinically detectable source of infection, it was significantly higher in culture positives.
Indexed as
Identifiers
26019777PMC4442833What OpenQuestion holds
Registered trials
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