Evidence map›Paper›PMID 26019759›Full record

ArticleInternational journal of stem cells2015

Combination cell therapy with mesenchymal stem cells and neural stem cells for brain stroke in rats.

Seyed Mojtaba Hosseini, Mohammad Farahmandnia, Zahra Razi, Somayeh Delavari, Benafsheh Shakibajahromi, Fatemeh Sabet Sarvestani, Sepehr Kazemi, Maryam Semsar

Abstract read
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In one paragraph

Article in International journal of stem cells, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seyed Mojtaba HosseiniStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran ; Cell and Molecular Student Research Group, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran ; Stem Cell laboratory, Department of Anatomy, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad FarahmandniaStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran ; Cell and Molecular Student Research Group, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Zahra RaziStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran ; Cell and Molecular Student Research Group, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Somayeh DelavariStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran ; Cell and Molecular Student Research Group, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Benafsheh ShakibajahromiStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran ; Cell and Molecular Student Research Group, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Fatemeh Sabet SarvestaniStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran ; Cell and Molecular Student Research Group, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Sepehr KazemiStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran ; Cell and Molecular Student Research Group, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryam SemsarStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran ; Cell and Molecular Student Research Group, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesBrain stroke is the second most important events that lead to disability and morbidity these days. Although, stroke is important, there is no treatment for curing this problem. Nowadays, cell therapy has opened a new window for treating central nervous system disease. In some previous studies the Mesenchymal stem cells and neural stem cells. In this study, we have designed an experiment to assess the combination cell therapy (Mesenchymal and Neural stem cells) effects on brain stroke. METHOD AND MATERIALS: The Mesenchymal stem cells were isolated from adult rat bone marrow and the neural stem cells were isolated from ganglion eminence of rat embryo 14 days. The Mesenchymal stem cells were injected 1 day after middle cerebral artery occlusion (MCAO) and the neural stem cells transplanted 7 day after MCAO. After 28 days, the neurological outcomes and brain lesion volumes were evaluated. Also, the activity of Caspase 3 was assessed in different groups.

resultThe group which received combination cell therapy had better neurological examination and less brain lesion. Also the combination cell therapy group had the least Caspase 3 activity among the groups.

conclusionsThe combination cell therapy is more effective than Mesenchymal stem cell therapy and neural stem cell therapy separately in treating the brain stroke in rats.

Indexed as

Brain strokeCombination cell therapyMesenchymal stem cellsNeural stem cells

Identifiers

PMID26019759
PMCPMC4445714

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.