ArticleCellular and molecular bioengineering2015
Impulsive Enzymes: A New Force in Mechanobiology.
Article in Cellular and molecular bioengineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 39 citations in OpenAlex.
- Metareview: a survey of active matter reviews.The European physical journal. E, Soft matter · 2025Review
- Single molecule-driven nanomotors reveal the dynamic-disordered chemomechanical transduction of active enzymes.Science advances · 2025Article
- Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery.Polymers · 2021Review
- The many flavours of mechanochemistry and its plausible conceptual underpinnings.Nature reviews. Chemistry · 2021Review
- Surface adhesion of viruses and bacteria: Defend only and/orMRS advances · 2021Article
- Master curve of boosted diffusion for 10 catalytic enzymes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mechanobiology of dynamic enzyme systems.APL bioengineering · 2020Article
- Glucose 6 phosphatase dehydrogenase (G6PD) and neurodegenerative disorders: Mapping diagnostic and therapeutic opportunities.Genes & diseases · 2017Review
- Enzyme Catalysis To Power Micro/Nanomachines.ACS nano · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We review studies that quantify newly discovered forces from single enzymatic reactions. These forces arise from the conversion of chemical energy to kinetic energy, which can be harnessed to direct diffusion of the enzyme up a concentration gradient of substrate, a novel phenomenon of molecular chemotaxis. When immobilized, enzymes can move fluid around them and perform directional pumping in microfluidic chambers. Because of the extensive array of enzymes in biological cells, we also develop three new hypotheses: that enzymatic self diffusion can assist in organizing signaling pathways in cells, can assist in pumping of fluid in cells, and can impose biologically significant forces on organelles, which will be manifested as stochastic motion not explained by thermal forces or myosin II. Such mechanochemical phenomena open up new directions in research in mechanobiology in which all enzymes, in addition to their primary function as catalysts for reactions, may have secondary functions as initiators of mechanosensitive transduction pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.