Observational studyWorld journal of gastroenterology2015
Novel immunological and nutritional-based prognostic index for gastric cancer.
Observational study in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 7 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Clinicopathological and prognostic significance of platelet-lymphocyte ratio (PLR) in gastric cancer: an updated meta-analysis.World journal of surgical oncology · 2020Pooled it
- The prognostic role of platelet-to-lymphocyte ratio on overall survival in gastric cancer: a systematic review and meta-analysis.BMC gastroenterology · 2020Pooled it
- The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: Systematic review and meta-analysis.Scientific reports · 2017Pooled it
- Neutrophil-to-lymphocyte ratio as prognostic indicator in gastrointestinal cancers: a systematic review and meta-analysis.Oncotarget · 2017Pooled it
- Platelet-lymphocyte ratio acts as an indicator of poor prognosis in patients with breast cancer.Oncotarget · 2017Pooled it
- Prognostic nutritional index as a prognostic biomarker for survival in digestive system carcinomas.Oncotarget · 2016Pooled it
- Clinicopathological and prognostic significance of platelet to lymphocyte ratio in patients with gastric cancer.Oncotarget · 2016Pooled it
- Association between preoperative controlling nutritional status score and surgical site infection following instrumented posterior lumbar interbody fusion.Frontiers in surgery · 2026Article
- A personalized prognostic model based on preoperative body composition and nutritional parameters for gastric cancer patients receiving neoadjuvant chemotherapy.Frontiers in immunology · 2026Article
- A Predictive Model for Postoperative Metastasis in Gastric Cancer Based on Preoperative Inflammatory Markers: A Retrospective Cohort Study from Western China.Cancer management and research · 2026Article
- Developing a predictive model for healing of clinically relevant pancreatic fistulas post-pancreatoduodenectomy based on clinical and imaging nutritional status.Japanese journal of radiology · 2025Article
- Combined albumin and CEA improve prognostic prediction in resectable gastric cancer.Scientific reports · 2025Article
- Inflammatory and nutritional markers predict response and prognosis of patients with locally advanced gastric cancer receiving neoadjuvant immunochemotherapy.BMC gastroenterology · 2025Article
- Article
- The relationship between splenic dose and radiation-induced lymphopenia.Journal of radiation research · 2024Article
- Prognostic nutritional index in predicting survival of patients with gastric or gastroesophageal junction adenocarcinoma: A systematic review.World journal of gastrointestinal oncology · 2024Article
- Controlling Nutritional Status (CONUT) score is a prognostic marker in III-IV NSCLC patients receiving first-line chemotherapy.BMC cancer · 2023Article
- Novel prognostic indicator combining inflammatory indicators and tumor markers for gastric cancer.World journal of surgical oncology · 2023Article
- Value of a preoperative prognostic nutritional index for the prognostic evaluation of gastric neuroendocrine carcinoma patients.Frontiers in nutrition · 2023Article
- Preoperative low muscle mass and malnutrition affect the clinical prognosis of locally advanced gastric cancer patients undergoing radical surgery.Frontiers in oncology · 2023Article
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Authors and funding
10 authors.
Funding
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Abstract
aimTo assess the prognostic significance of immunological and nutritional-based indices, including the prognostic nutritional index (PNI), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio in gastric cancer.
methodsWe retrospectively reviewed 632 gastric cancer patients who underwent gastrectomy between 1998 and 2008. Areas under the receiver operating characteristic curve were calculated to compare the predictive ability of the indices, together with estimating the sensitivity, specificity and agreement rate. Univariate and multivariate analyses were performed to identify risk factors for overall survival (OS). Propensity score analysis was performed to adjust variables to control for selection bias.
resultsEach index could predict OS in gastric cancer patients in univariate analysis, but only PNI had independent prognostic significance in multivariate analysis before and after adjustment with propensity scoring (hazard ratio, 1.668; 95% confidence interval: 1.368-2.035). In subgroup analysis, a low PNI predicted a significantly shorter OS in patients with stage II-III disease (P = 0.019, P < 0.001), T3-T4 tumors (P < 0.001), or lymph node metastasis (P < 0.001). Canton score, a combination of PNI, NLR, and platelet, was a better indicator for OS than PNI, with the largest area under the curve for 12-, 36-, 60-mo OS and overall OS (P = 0.022, P = 0.030, P < 0.001, and P = 0.024, respectively). The maximum sensitivity, specificity, and agreement rate of Canton score for predicting prognosis were 84.6%, 34.9%, and 70.1%, respectively.
conclusionPNI is an independent prognostic factor for OS in gastric cancer. Canton score can be a novel preoperative prognostic index in gastric cancer.
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