ReviewWorld journal of gastroenterology2015
Sphincter of Oddi dysfunction Type III: New studies suggest new approaches are needed.
Review in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Endoscopic sphincterotomy for adults with biliary sphincter of Oddi dysfunction.The Cochrane database of systematic reviews · 2024Pooled it
- Endoscopic Management of Recurrent Acute Pancreatitis.Journal of clinical medicine · 2025Review
- Reassessing the role of nitric oxide in the pathogenesis of sphincter of Oddi dysfunction.Gastroenterology report · 2025Review
- Biliary Dyskinesia with Reduced Gallbladder Ejection Fraction: A Diagnostic and Therapeutic Shift in Management.Journal of Brown hospital medicine · 2025Article
- Turkish Society of Gastroenterology: Pancreas Working Group, Acute Pancreatitis Committee Consensus Report.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Review
- Current treatment of biliary Sphincter of Oddi Dysfunction.Frontiers in medicine · 2024Review
- Idiopathic acute pancreatitis (IAP)-a review of the literature and algorithm proposed for the diagnostic work-up of IAP.Translational gastroenterology and hepatology · 2024Review
- Dysfunction of Biliary Sphincter of Oddi-Clinical, Diagnostic and Treatment Challenges.Journal of clinical medicine · 2023Review
- Update on Sphincter of Oddi Dysfunction: A Review.Journal of clinical and translational hepatology · 2022Review
- Gallbladder Agenesis without Additional Biliary Tracts Abnormality.Case reports in gastrointestinal medicine · 2022Article
- Increased Risk of Acute Pancreatitis with Codeine Use in Patients with a History of Cholecystectomy.Digestive diseases and sciences · 2020Article
- Idiopathic acute pancreatitis: a review on etiology and diagnostic work-up.Clinical journal of gastroenterology · 2019Review
- Article
- [Importance of functional diagnostics in gastroenterology].Der Internist · 2018Review
- Gall Bladder Agenesis: A Rare Embryonic Cause of Recurrent Biliary Colic.The American journal of case reports · 2017Article
- Translational and clinical perspectives on sphincter of Oddi dysfunction.Clinical and experimental gastroenterology · 2016Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sphincter of Oddi dysfunction (SOD) has been classified into three types based upon the presence or absence of objective findings including liver test abnormalities and bile duct dilatation. Type III is the most controversial and is classified as biliary type pain in the absence of any these objective findings. Many prior studies have shown that the clinical response to endoscopic therapy is higher based upon the presence of these objective criteria. However, there has been variable correlation of the manometry findings to outcome after endoscopic therapy. Nevertheless, manometry and sphincterotomy has been recommended for Type III patients given the overall response rate of 33%, although the reported response rates are highly variable. However, all of the prior data was non-blinded and non-randomized with variable follow-up. The evaluating predictors in SOD study - a prospective randomized blinded sham controlled one year outcome study showed no correlation between manometric findings and outcome after sphincterotomy. Furthermore, patients receiving sham therapy had a statistically significantly better outcome than those undergoing biliary or dual sphincterotomy. This study calls into question the whole concept of SOD Type III and, based upon prior physiologic studies, one can suggest that SOD Type III likely represents a right upper quadrant functional abdominal pain syndrome and should be treated as such.
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Registered trials
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