Evidence map›Paper›PMID 26019371›Full record

ArticleTetrahedron letters2015

Tailored fragments of roseophilin selectively antagonize Mcl-1

Jack D Bracken, Andrew D Carlson, James H Frederich, Mai Nguyen, Gordon C Shore, Patrick G Harran

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jack D BrackenDepartment of Chemistry and Biochemistry, University of California at Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA 90095, United States.
Andrew D CarlsonDepartment of Chemistry and Biochemistry, University of California at Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA 90095, United States.
James H FrederichDepartment of Chemistry and Biochemistry, University of California at Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA 90095, United States.
Mai NguyenDepartment of Biochemistry and Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada.
Gordon C ShoreDepartment of Biochemistry and Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada.
Patrick G HarranDepartment of Chemistry and Biochemistry, University of California at Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA 90095, United States.
University of California, Los Angeles · USMcGill University · CA

Funding

CHEMISTRY BIOLOGY INTERFACE TRAINING PROGRAMT32GM008496 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYNARD, HEATHER D · 1993 to 2019
$6.3M
Fully Synthetic Prodiginines as Probes of Protein-Protein Interactions RegulatingR01CA184772 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARRAN, PATRICK G. · 2014 to 2019
$1.8M
NCI NIH HHS R01 CA184772NIGMS NIH HHS T32 GM008496
6 · The paper itself

Abstract

We have discovered a fragment of the natural product roseophilin, a member of the prodiginine family, that antagonizes Mcl-1 functions in a liposome-based assay for mitochondrial membrane permeabilization. By tailoring this substance such that it can participate in salt bridging with the protein surface, we have prepared the first prodiginine inspired structure that shows direct, saturable binding to a recombinant Bcl-2 family member

Indexed as

Bcl-2Mcl-1ObatoclaxRoseophilinTetrazole

Identifiers

PMID26019371
PMCPMC4442084
OpenAlexW1965977355

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.