Evidence map›Paper›PMID 26019370›Full record

ArticleTetrahedron letters2015

Synthesis of a polymerizable, bivalent glycan mimetic of the HIV envelope spike gp120.

Eric T Sletten, Riley L Svec, Hien M Nguyen

Abstract read
In one paragraph

Article in Tetrahedron letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eric T SlettenDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, USA.
Riley L SvecDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, USA.
Hien M NguyenDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, USA.

Funding

Tailoring Structures of Sulfated Oligosaccharides for Modulating Heparanase ActivityR01GM098285 · NIGMS · WAYNE STATE UNIVERSITY · PI NGUYEN, HIEN M · 2012 to 2022
$3.5M
NIGMS NIH HHS R01 GM098285
6 · The paper itself

Abstract

A synthetic study on the creation of a bivalent, ROMP capable monomer has the ability to be polymerized into the corresponding neo-glycopolymer mimetic of the surface glycans on gp120 envelope spike of the HIV virus. In our approach, we have developed a new strategy for orthogonally attaching both the terminal Manα1-2Man disaccharide unit of the D1 arm of Man9GlcNAc2 of HIV gp120 and the terminal Manα1-2 unit of its D2 arm to a bivalent scaffold to produce the corresponding polymerizable monomer. The Manα1-2 saccharide moieties were assembled using a nickel catalyst, Ni(4-F-PhCN)

Indexed as

Carbohydrate SynthesisGlycopolymerHIVNickel Catalyzed

Identifiers

PMID26019370
PMCPMC4442089

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.