ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Sensorimotor processing in the newborn rat red nucleus during active sleep.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 48 citations in OpenAlex.
- Twitching in sleeping premature infants provides a sensitive behavioral assay of early motor control.iScience · 2026Article
- Article
- REM-sleep twitching in adults and the maintenance of specialized sensorimotor systems.Current biology : CB · 2026Review
- Motor cortex activity during sleep and wake movements sharpens across development but continues to lag the red nucleus.Scientific reports · 2026Article
- Twitching in sleeping premature infants provides a sensitive behavioral assay of early motor control.bioRxiv : the preprint server for biology · 2026Article
- Do twitching and twitch-spindle coupling differ between N2 and N3 sleep in 6-month-olds?bioRxiv : the preprint server for biology · 2025Article
- More Than a Small Brain: The Importance of Studying Neural Function during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Developmentally Unique Cerebellar Processing Prioritizes Self- over Other-Generated Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Developmentally unique cerebellar processing prioritizes self-over other-generated movements.bioRxiv : the preprint server for biology · 2024Article
- A Thalamocortical Perspective on Sleep Spindle Alterations in Neurodevelopmental Disorders.Current sleep medicine reports · 2024Review
- Glutamatergic cerebellar neurons differentially contribute to the acquisition of motor and social behaviors.Nature communications · 2023Article
- Protracted development of motor cortex constrains rich interpretations of infant cognition.Trends in cognitive sciences · 2023Review
- Neuro-orchestration of sleep and wakefulness.Nature neuroscience · 2023Review
- Understanding Sleep Regulation in Normal and Pathological Conditions, and Why It Matters.Journal of Huntington's disease · 2023Review
- Sleep, plasticity, and sensory neurodevelopment.Neuron · 2022Review
- Rapid eye movement sleep behaviour disorder: Past, present, and future.Journal of sleep research · 2022Review
- The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion.eLife · 2022Article
- Review
- Sensory Coding of Limb Kinematics in Motor Cortex across a Key Developmental Transition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Spatiotemporal organization of myoclonic twitching in sleeping human infants.Developmental psychobiology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sensory feedback from sleep-related myoclonic twitches is thought to drive activity-dependent development in spinal cord and brain. However, little is known about the neural pathways involved in the generation of twitches early in development. The red nucleus (RN), source of the rubrospinal tract, has been implicated in the production of phasic motor activity during active sleep in adults. Here we hypothesized that the RN is also a major source of motor output for twitching in early infancy, a period when twitching is an especially abundant motor behavior. We recorded extracellular neural activity in the RN during sleep and wakefulness in 1-week-old unanesthetized rats. Neurons in the RN fired phasically before twitching and wake movements of the contralateral forelimb. A subpopulation of neurons in the RN exhibited a significant peak of activity after forelimb movement onset, suggesting reafferent sensory processing. Consistent with this observation, manual stimulation of the forelimb evoked RN responses. Unilateral inactivation of the RN using a mixture comprising GABAA, GABAB, and glycine receptor agonists caused an immediate and temporary increase in motor activity followed by a marked and prolonged decrease in twitching and wake movements. Altogether, these data support a causal role for the RN in infant motor behavior. Furthermore, they indicate that twitching, which is characterized by discrete motor output and reafferent input, provides an opportunity for sensorimotor integration and activity-dependent development of topography within the newborn RN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.