Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Abnormal contrast responses in the extrastriate cortex of blindsight patients.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Personalized Visual Perceptual Learning Digital Therapy for Visual Field Defects Following Stroke: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Generalisation of training-induced recovery in occipital stroke: neurochemical and fMRI correlates.bioRxiv : the preprint server for biology · 2026Article
- Voxel-Based Lesion-Symptom Mapping Localizes Residual Visual Function in Hemianopia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Network Localization of Unconscious Visual Perception in Blindsight.Annals of neurology · 2022Article
- Remodeling of lateral geniculate nucleus projections to extrastriate area MT following long-term lesions of striate cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Rehabilitation of visual perception in cortical blindness.Handbook of clinical neurology · 2022Review
- Functional preservation and enhanced capacity for visual restoration in subacute occipital stroke.Brain : a journal of neurology · 2020Article
- The Superior Colliculus and Amygdala Support Evaluation of Face Trait in Blindsight.Frontiers in neurology · 2020Article
- Functional interactions in patients with hemianopia: A graph theory-based connectivity study of resting fMRI signal.PloS one · 2020Article
- Article
- Subcortical pathways to extrastriate visual cortex underlie residual vision following bilateral damage to V1.Neuropsychologia · 2019Article
- Visual training in hemianopia alters neural activity in the absence of behavioural improvement: a pilot study.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2018Article
- Blindsight relies on a functional connection between hMT+ and the lateral geniculate nucleus, not the pulvinar.PLoS biology · 2018Article
- Visual discrimination training improves Humphrey perimetry in chronic cortically induced blindness.Neurology · 2017Article
- Lights from the Dark: Neural Responses from a Blind Visual Hemifield.Frontiers in neuroscience · 2017Article
- Blindsight and Unconscious Vision: What They Teach Us about the Human Visual System.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2016Review
- Probing Human Visual Deficits with Functional Magnetic Resonance Imaging.Annual review of vision science · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
When the human primary visual cortex (V1) is damaged, the dominant geniculo-striate pathway can no longer convey visual information to the occipital cortex. However, many patients with such damage retain some residual visual function that must rely on an alternative pathway directly to extrastriate occipital regions. This residual vision is most robust for moving stimuli, suggesting a role for motion area hMT+. However, residual vision also requires high-contrast stimuli, which is inconsistent with hMT+ sensitivity to contrast in which even low-contrast levels elicit near-maximal neural activation. We sought to investigate this discrepancy by measuring behavioral and neural responses to increasing contrast in patients with V1 damage. Eight patients underwent behavioral testing and functional magnetic resonance imaging to record contrast sensitivity in hMT+ of their damaged hemisphere, using Gabor stimuli with a spatial frequency of 1 cycle/°. The responses from hMT+ of the blind hemisphere were compared with hMT+ and V1 responses in the sighted hemisphere of patients and a group of age-matched controls. Unlike hMT+, neural responses in V1 tend to increase linearly with increasing contrast, likely reflecting a dominant parvocellular channel input. Across all patients, the responses in hMT+ of the blind hemisphere no longer showed early saturation but increased linearly with contrast. Given the spatiotemporal parameters used in this study and the known direct subcortical projections from the koniocellular layers of the lateral geniculate nucleus to hMT+, we propose that this altered contrast sensitivity in hMT+ could be consistent with input from the koniocellular pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.