ArticleJournal of neurophysiology2015
Experimental muscle pain increases variability of neural drive to muscle and decreases motor unit coherence in tremor frequency band.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does pain influence control of muscle force? A systematic review and meta-analysis.European journal of pain (London, England) · 2025Pooled it
- Differential changes in the effective neural drive following new motor skill acquisition between vastus lateralis and medialis.European journal of applied physiology · 2026Article
- Frequency-specific intermuscular coherence of synergistic muscles during an isometric force generation task.Frontiers in neural circuits · 2025Article
- Does Muscle Pain Induce Alterations in the Pelvic Floor Motor Unit Activity Properties in Interstitial Cystitis/Bladder Pain Syndrome? A High-Density sEMG-Based Study.Sensors (Basel, Switzerland) · 2024Article
- Deficits in neuromuscular control of increasing force in patients with chronic lateral epicondylitis.Frontiers in physiology · 2023Article
- Variations in Muscle Activity and Exerted Torque During Temporary Blood Flow Restriction in Healthy Individuals.Frontiers in bioengineering and biotechnology · 2021Article
- Origins of Common Neural Inputs to Different Compartments of the Extensor Digitorum Communis Muscle.Scientific reports · 2017Article
- Altered Motor Unit Discharge Coherence in Paretic Muscles of Stroke Survivors.Frontiers in neurology · 2017Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
It has been observed that muscle pain influences force variability and low-frequency (<3 Hz) oscillations in the neural drive to muscle. In this study, we aimed to investigate the effect of experimental muscle pain on the neural control of muscle force at higher frequency bands, associated with afferent feedback (alpha band, 5-13 Hz) and with descending cortical input (beta band, 15-30 Hz). Single-motor unit activity was recorded, in two separate experimental sessions, from the abductor digiti minimi (ADM) and tibialis anterior (TA) muscles with intramuscular wire electrodes, during isometric abductions of the fifth finger at 10% of maximal force [maximum voluntary contraction (MVC)] and ankle dorsiflexions at 25% MVC. The contractions were repeated under three conditions: no pain (baseline) and after intramuscular injection of isotonic (0.9%, control) and hypertonic (5.8%, painful) saline. The results showed an increase of the relative power of both the force signal and the neural drive at the tremor frequency band (alpha, 5-13 Hz) between the baseline and hypertonic (painful) conditions for both muscles (P < 0.05) but no effect on the beta band. Additionally, the strength of motor unit coherence was lower (P < 0.05) in the hypertonic condition in the alpha band for both muscles and in the beta band for the ADM. These results indicate that experimental muscle pain increases the amplitude of the tremor oscillations because of an increased variability of the neural control (common synaptic input) in the tremor band. Moreover, the concomitant decrease in coherence suggests an increase in independent input in the tremor band due to pain.
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