Evidence map›Paper›PMID 26019294›Full record

ArticleJournal of leukocyte biology2015

Control of IFN-γ production and regulatory function by the inducible nuclear protein IκB-ζ in T cells.

Takashi MaruYama, Shuhei Kobayashi, Kouetsu Ogasawara, Akihiko Yoshimura, WanJun Chen, Tatsushi Muta

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Regulation and Function of the Atypical IκBs-Bcl-3, IκBEuropean journal of immunology · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. NF-κB in control of regulatory T cell development, identity, and function.Journal of molecular medicine (Berlin, Germany) · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Essential role of IκBEuropean journal of immunology · 2019
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Takashi MaruYama*Laboratory of Cell Recognition and Response, Graduate School of Life Sciences, and Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan; School of Medicine, Gifu University, Gifu, Japan; Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan; and Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA ta-maru@umin.ac.jp.
Shuhei Kobayashi*Laboratory of Cell Recognition and Response, Graduate School of Life Sciences, and Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan; School of Medicine, Gifu University, Gifu, Japan; Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan; and Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Kouetsu Ogasawara*Laboratory of Cell Recognition and Response, Graduate School of Life Sciences, and Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan; School of Medicine, Gifu University, Gifu, Japan; Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan; and Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Akihiko Yoshimura*Laboratory of Cell Recognition and Response, Graduate School of Life Sciences, and Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan; School of Medicine, Gifu University, Gifu, Japan; Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan; and Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
WanJun Chen*Laboratory of Cell Recognition and Response, Graduate School of Life Sciences, and Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan; School of Medicine, Gifu University, Gifu, Japan; Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan; and Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Tatsushi Muta*Laboratory of Cell Recognition and Response, Graduate School of Life Sciences, and Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan; School of Medicine, Gifu University, Gifu, Japan; Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan; and Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Gifu University · JPKeio University · JPNational Institute of Dental and Craniofacial Research · USTohoku University · JP

Funding

TGF-beta Regulation of Mucosal and Systemic T Cell Immunity and ToleranceZIADE000101 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI CHEN, WANJUN · 2009 to 2025
$36.9M
6 · The paper itself

Abstract

The transcriptional regulator IκB-ζ is important for the control of apoptosis in keratinocytes. Thus, IκB-ζ-deficient mice develop autoimmune diseases, such as Sjögren's syndrome. However, T cells also play a pivotal role in Sjögren's syndrome. To study the role of IκB-ζ in T cells, we generated T cell-specific, IκB-ζ-deficient mice. We observed increased numbers of peripheral effector/memory CD4(+) cells and IFN-γ-producing CD4(+) cells in 3-week-old mice. We found that IκB-ζ can be up-regulated by TGF-β1 in naïve CD4(+) T cells and that it negatively regulates IFN-γ expression. In addition, we generated Treg-specific, IκB-ζ deficient mice and found that IκB-ζ is dispensable for the plasticity and stability of Tregs. However, Tregs from T cell-specific, IκB-ζ-deficient mice have reduced immunoregulatory function. Thus, our data reveal a previously unappreciated role for IκB-ζ in IFN-γ production in T cells and the immunoregulatory function of Tregs.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsColitisForkhead Transcription FactorsGene Expression RegulationHEK293 CellsHomeostasisHumansImmune ToleranceInterferon-gammaMice, Inbred C57BLMice, KnockoutNuclear ProteinsT-Lymphocytes, RegulatoryTransforming Growth Factor beta1Adaptor Proteins, Signal TransducingForkhead Transcription FactorsFoxp3 protein, mouseInterferon-gammaNfkbiz protein, mouseNuclear ProteinsTransforming Growth Factor beta1cytokineT lymphocytetranscriptional regulator

Identifiers

PMID26019294
PMCPMC4541499
OpenAlexW2194619287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.