ArticleNeurology2015
Longitudinal patient-oriented outcomes in neuropathy: Importance of early detection and falls.
Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- [The nervous system and communication: polyneuropathy and the role of the peripheral nervous system].Zeitschrift fur Gerontologie und Geriatrie · 2026Review
- A Multicenter, Prospective, Observational, and Single-Arm Interventional Study of Mirogabalin in Diabetic Peripheral Neuropathic Pain: Rationale and Design of Dia-NeP.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- Artificial Intelligence Algorithm to Screen for Diabetic Neuropathy: A Pilot Study.Biomedicines · 2025Article
- The association between anserine bursa pain and fall susceptibility: a prospective analysis of the osteoarthritis initiative.Frontiers in aging · 2025Article
- Peripheral neuropathy, an independent risk factor for falls in the elderly, impairs stepping as a postural control mechanism: A case-cohort study.Journal of the peripheral nervous system : JPNS · 2024Article
- The Quality of Life after Endometrial Cancer Study: Baseline Characteristics and Patient-Reported Outcomes.Current oncology (Toronto, Ont.) · 2024Article
- Prevalence and Risk Factors of Distal Symmetric Polyneuropathy Among Predominantly Non-Hispanic Black, Low-Income Patients.Neurology · 2024Article
- Dynapenic abdominal obesity and susceptibility to fall: a prospective analysis of the Osteoarthritis Initiative.Frontiers in nutrition · 2023Article
- Effect of strength training on functional outcomes and strength in patients with polyneuropathy: A scoping review.Frontiers in physiology · 2023Article
- Diabetes Distal Peripheral Neuropathy: Subtypes and Diagnostic and Screening Technologies.Journal of diabetes science and technology · 2022Review
- COVID-19 and the hidden threat of diabetic microvascular complications.Therapeutic advances in endocrinology and metabolism · 2022Review
- Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise.International journal of environmental research and public health · 2021Review
- Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology.Obesity (Silver Spring, Md.) · 2021Article
- Association of Cardiovascular Risk Burden With Risk and Progression of Disability: Mediating Role of Cardiovascular Disease and Cognitive Decline.Journal of the American Heart Association · 2020Article
- Central Obesity is Associated With Neuropathy in the Severely Obese.Mayo Clinic proceedings · 2020Observational
- The Multidimensional Prognostic Index Predicts Falls in Older People: An 8-Year Longitudinal Cohort Study of the Osteoarthritis Initiative.Journal of the American Medical Directors Association · 2020Article
- [Polyneuropathy in older individuals].Der Internist · 2020Review
- Vibrotactile perception on the sole of the foot in an older group of people with normal glucose tolerance and type 2 diabetes.SAGE open medicine · 2020Article
- Diabetic neuropathy.Nature reviews. Disease primers · 2019Article
- The pace and prognosis of peripheral sensory loss in advanced age: association with gait speed and falls.BMC geriatrics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveTo evaluate longitudinal patient-oriented outcomes in peripheral neuropathy over a 14-year time period including time before and after diagnosis.
methodsThe 1996-2007 Health and Retirement Study (HRS)-Medicare Claims linked database identified incident peripheral neuropathy cases (ICD-9 codes) in patients ≥65 years. Using detailed demographic information from the HRS and Medicare claims, a propensity score method identified a matched control group without neuropathy. Patient-oriented outcomes, with an emphasis on self-reported falls, pain, and self-rated health (HRS interview), were determined before and after neuropathy diagnosis. Generalized estimating equations were used to assess differences in longitudinal outcomes between cases and controls.
resultsWe identified 953 peripheral neuropathy cases and 953 propensity-matched controls. The mean (SD) age was 77.4 (6.7) years for cases, 76.9 (6.6) years for controls, and 42.1% had diabetes. Differences were detected in falls 3.0 years before neuropathy diagnosis (case vs control; 32% vs 25%, p = 0.008), 5.0 years for pain (36% vs 27%, p = 0.002), and 5.0 years for good to excellent self-rated health (61% vs 74%, p < 0.0001). Over time, the proportion of fallers increased more rapidly in neuropathy cases compared to controls (p = 0.002), but no differences in pain (p = 0.08) or self-rated health (p = 0.9) were observed.
conclusionsIn older persons, differences in falls, pain, and self-rated health can be detected 3-5 years prior to peripheral neuropathy diagnosis, but only falls deteriorates more rapidly over time in neuropathy cases compared to controls. Interventions to improve early peripheral neuropathy detection are needed, and future clinical trials should incorporate falls as a key patient-oriented outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.