ArticleClinical cancer research : an official journal of the American Association for Cancer Research2015
MR-Guided Near-Infrared Spectral Tomography Increases Diagnostic Performance of Breast MRI.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Deep Learning Enables Fast and Accurate Quantification of MRI-Guided Near-Infrared Spectral Tomography for Breast Cancer Diagnosis.IEEE transactions on medical imaging · 2025Article
- Model-Based Convolution Neural Network for 3D Near-Infrared Spectral Tomography.IEEE transactions on medical imaging · 2025Article
- MRI-Guided Near-Infrared Spectroscopic Tomography (MRg-NIRST) Imaging System With Wearable Breast Optical Interface for Breast Cancer Imaging.IEEE transactions on bio-medical engineering · 2025Article
- Two-stage classification strategy for breast cancer diagnosis using ultrasound-guided diffuse optical tomography and deep learning.Journal of biomedical optics · 2023Article
- FDU-Net: Deep Learning-Based Three-Dimensional Diffuse Optical Image Reconstruction.IEEE transactions on medical imaging · 2023Article
- Development of a theranostic preclinical fluorescence molecular tomography/cone beam CT-guided irradiator platform.Biomedical optics express · 2022Article
- Method to improve the localization accuracy and contrast recovery of lesions in separately acquired X-ray and diffuse optical tomographic breast imaging.Biomedical optics express · 2022Article
- Image processing improvements afford second-generation handheld optoacoustic imaging of breast cancer patients.Photoacoustics · 2022Article
- 2.5 Hz sample rate time-domain near-infrared optical tomography based on SPAD-camera image tissue hemodynamics.Biomedical optics express · 2022Article
- Prospective assessment of adjunctive ultrasound-guided diffuse optical tomography in women undergoing breast biopsy: Impact on BI-RADS assessments.European journal of radiology · 2021Article
- Performance assessment of MRI guided continuous wave near-infrared spectral tomography for breast imaging.Biomedical optics express · 2021Article
- A review of optical breast imaging: Multi-modality systems for breast cancer diagnosis.European journal of radiology · 2020Review
- Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging.Journal of biomedical optics · 2019Article
- Back-propagation neural network-based reconstruction algorithm for diffuse optical tomography.Journal of biomedical optics · 2018Article
- Weighting function effects in a direct regularization method for image-guided near-infrared spectral tomography of breast cancer.Biomedical optics express · 2018Article
- Direct Regularization From Co-Registered Contrast MRI Improves Image Quality of MRI-Guided Near-Infrared Spectral Tomography of Breast Lesions.IEEE transactions on medical imaging · 2018Article
- Addition of T2-guided optical tomography improves noncontrast breast magnetic resonance imaging diagnosis.Breast cancer research : BCR · 2017Article
- Quantitative photoacoustic image reconstruction improves accuracy in deep tissue structures.Biomedical optics express · 2016Article
- Multiobjective guided priors improve the accuracy of near-infrared spectral tomography for breast imaging.Journal of biomedical optics · 2016Article
- Portable, parallel 9-wavelength near-infrared spectral tomography (NIRST) system for efficient characterization of breast cancer within the clinical oncology infusion suite.Biomedical optics express · 2016Article
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11 authors.
Funding
Abstract
purposeThe purpose of this study was to determine the diagnostically most important molecular biomarkers quantified by magnetic resonance-guided (MR) near-infrared spectral tomography (NIRST) that distinguish malignant breast lesions from benign abnormalities when combined with outcomes from clinical breast MRI. EXPERIMENTAL
designThe study was HIPAA compliant and approved by the Dartmouth Institutional Review Board, the NIH, the United States State Department, and Xijing Hospital. MR-guided NIRST evaluated hemoglobin, water, and lipid content in regions of interest defined by concurrent dynamic contrast-enhanced MRI (DCE-MRI) in the breast. MRI plus NIRST was performed in 44 subjects (median age, 46, age range, 20-81 years), 28 of whom had subsequent malignant pathologic diagnoses, and 16 had benign conditions. A subset of 30 subject examinations yielded optical data that met minimum sensitivity requirements to the suspicious lesion and were included in the analyses of diagnostic performance.
resultsIn the subset of 30 subject examinations meeting minimum optical data sensitivity criterion, the MR-guided NIRST separated malignant from benign lesions using total hemoglobin (HbT; P < 0.01) and tissue optical index (TOI; P < 0.001). Combined MRI plus TOI data caused one false positive and 1 false negative, and produced the best diagnostic performance, yielding an AUC of 0.95, sensitivity of 95%, specificity of 89%, positive predictive value of 95%, and negative predictive value of 89%, respectively.
conclusionsMRI plus NIRST results correlated well with histopathologic diagnoses and could provide additional information to reduce the number of MRI-directed biopsies.
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