ArticleGenome biology and evolution2015
Complete Genome Sequence and Transcriptomic Analysis of the Novel Pathogen Elizabethkingia anophelis in Response to Oxidative Stress.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- capD deletion in the Elizabethkingia miricola capsular locus leads to capsule production deficiency and reduced virulence.Veterinary research · 2024Article
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- A Rare Case of Infective Endocarditis with Recurrent Fever Caused byInfection and drug resistance · 2024Article
- Epidemiology and Characteristics ofMicroorganisms · 2022Review
- Genomic analysis ofCurrent research in microbial sciences · 2022Article
- The Integrative and Conjugative Element ICEMicrobiology spectrum · 2021Article
- Structural characterization of a Type B chloramphenicol acetyltransferase from the emerging pathogen Elizabethkingia anophelis NUHP1.Scientific reports · 2021Article
- MBLs, Rather Than Efflux Pumps, Led to Carbapenem Resistance in Fosfomycin and Aztreonam/Avibactam ResistantInfection and drug resistance · 2021Article
- Pan-genome analysis of Riemerella anatipestifer reveals its genomic diversity and acquired antibiotic resistance associated with genomic islands.Functional & integrative genomics · 2020Article
- Article
- Review
- Bacterial Communities and Virulence Associated with Pine Wood NematodeInternational journal of molecular sciences · 2019Article
- Article
- Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain.Nature communications · 2017Article
- Article
- Genomic, Physiologic, and Symbiotic Characterization ofFrontiers in microbiology · 2017Article
- Genomic epidemiology and global diversity of the emerging bacterial pathogen Elizabethkingia anophelis.Scientific reports · 2016Article
- The genome and genetics of a high oxidative stress tolerant Serratia sp. LCN16 isolated from the plant parasitic nematode Bursaphelenchus xylophilus.BMC genomics · 2016Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elizabethkingia anophelis is an emerging pathogen that can cause life-threatening infections in neonates, severely immunocompromised and postoperative patients. The lack of genomic information on E. anophelis hinders our understanding of its mechanisms of pathogenesis. Here, we report the first complete genome sequence of E. anophelis NUHP1 and assess its response to oxidative stress. Elizabethkingia anophelis NUHP1 has a circular genome of 4,369,828 base pairs and 4,141 predicted coding sequences. Sequence analysis indicates that E. anophelis has well-developed systems for scavenging iron and stress response. Many putative virulence factors and antibiotic resistance genes were identified, underscoring potential host-pathogen interactions and antibiotic resistance. RNA-sequencing-based transcriptome profiling indicates that expressions of genes involved in synthesis of an yersiniabactin-like iron siderophore and heme utilization are highly induced as a protective mechanism toward oxidative stress caused by hydrogen peroxide treatment. Chrome azurol sulfonate assay verified that siderophore production of E. anophelis is increased in the presence of oxidative stress. We further showed that hemoglobin facilitates the growth, hydrogen peroxide tolerance, cell attachment, and biofilm formation of E. anophelis NUHP1. Our study suggests that siderophore production and heme uptake pathways might play essential roles in stress response and virulence of the emerging pathogen E. anophelis.
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