ArticleExperimental brain research2015
Sleep alterations following exposure to stress predict fear-associated memory impairments in a rodent model of PTSD.
Article in Experimental brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents.Frontiers in behavioral neuroscience · 2021Pooled it
- Investigation of the impact of total sleep deprivation at home on the number of intrusive memories to an analogue trauma.Translational psychiatry · 2019Trial
- The Single-Prolonged Stress Model Fails to Produce Behavioral or Corticosterone Alterations in Rats.eNeuro · 2026Article
- The impacts of sex and the 5xFAD model of Alzheimer's disease on the sleep and spatial learning responses to feeding time.Frontiers in neurology · 2024Article
- Biomarkers of stress resilience: A review.Neuroscience applied · 2024Article
- On the basis of sex and sleep: the influence of the estrous cycle and sex on sleep-wake behavior.Frontiers in neuroscience · 2024Review
- The influence of sleep on fear extinction in trauma-related disorders.Neurobiology of stress · 2023Article
- Posttraumatic stress disorder (PTSD), sleep, and cardiovascular disease risk: A mechanism-focused narrative review.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022Review
- Controllable and Uncontrollable Stress Differentially Impact Fear Conditioned Alterations in Sleep and Neuroimmune Signaling in Mice.Life (Basel, Switzerland) · 2022Article
- Tick-borne encephalitis affects sleep-wake behavior and locomotion in infant rats.Cell & bioscience · 2022Article
- Fabp7 Is Required for Normal Sleep Suppression and Anxiety-Associated Phenotype following Single-Prolonged Stress in Mice.Neuroglia (Basel, Switzerland) · 2022Article
- Alexithymia and post-traumatic stress disorder symptoms in Chinese undergraduate students during the COVID-19 national lockdown: The mediating role of sleep problems and the moderating role of self-esteem.Frontiers in psychology · 2022Article
- The Many Faces of Sleep Disorders in Post-Traumatic Stress Disorder: An Update on Clinical Features and Treatment.Neuropsychobiology · 2022Review
- Disrupted Sleep Homeostasis and Altered Expressions of Clock Genes in Rats with Chronic Lead Exposure.Toxics · 2021Article
- Altered sleep behavior in a genetic mouse model of impaired fear extinction.Scientific reports · 2021Article
- Memory and Sleep: How Sleep Cognition Can Change the Waking Mind for the Better.Annual review of psychology · 2021Article
- Daily Optogenetic Stimulation of the Left Infralimbic Cortex Reverses Extinction Impairments in Male Rats Exposed to Single Prolonged Stress.Frontiers in behavioral neuroscience · 2021Article
- Roles for Sleep in Neural and Behavioral Plasticity: Reviewing Variation in the Consequences of Sleep Loss.Frontiers in behavioral neuroscience · 2021Review
- Sleep Power Spectral Density and Spindles in PTSD and Their Relationship to Symptom Severity.Frontiers in psychiatry · 2021Article
- Polysomnographic Sleep and Attentional Deficits in Traumatized North Korean Refugees.Nature and science of sleep · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Sleep abnormalities, such as insomnia, nightmares, hyper-arousal, and difficulty initiating or maintaining sleep, are diagnostic criteria of posttraumatic stress disorder (PTSD). The vivid dream state, rapid eye movement (REM) sleep, has been implicated in processing emotional memories. We have hypothesized that REM sleep is maladaptive in those suffering from PTSD. However, the precise neurobiological mechanisms regulating sleep disturbances following trauma exposure are poorly understood. Using single prolonged stress (SPS), a well-validated rodent model of PTSD, we measured sleep alterations in response to stressor exposure and over a subsequent 7-day isolation period during which the PTSD-like phenotype develops. SPS resulted in acute increases in REM sleep and transition to REM sleep, and decreased waking in addition to alterations in sleep architecture. The severity of the PTSD-like phenotype was later assessed by measuring freezing levels on a fear-associated memory test. Interestingly, the change in REM sleep following SPS was significantly correlated with freezing behavior during extinction recall assessed more than a week later. Reductions in theta (4-10 Hz) and sigma (10-15 Hz) band power during transition to REM sleep also correlated with impaired fear-associated memory processing. These data reveal that changes in REM sleep, transition to REM sleep, waking, and theta and sigma power may serve as sleep biomarkers to identify individuals with increased susceptibility to PTSD following trauma exposure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.