ArticleDong wu xue yan jiu = Zoological research2015
Purification and characterization of cholecystokinin from the skin of salamander Tylototriton verrucosus.
Article in Dong wu xue yan jiu = Zoological research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Article
- Protein Composition and Biomedical Potential of the Skin Secretion ofInternational journal of peptide research and therapeutics · 2021Article
- The Arsenal of Bioactive Molecules in the Skin Secretion of Urodele Amphibians.Frontiers in pharmacology · 2021Review
- Bv8-Like Toxin from the Frog Venom ofToxins · 2019Article
- Antimicrobial peptides in frog poisons constitute a molecular toxin delivery system against predators.Nature communications · 2017Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a group of intestinal hormones and neurotransmitters, cholecystokinins (CCKs) regulate and affect pancreatic enzyme secretion, gastrointestinal motility, pain hypersensitivity, digestion and satiety, and generally contain a DYMGWMDFG sequence at the C-terminus. Many CCKs have been reported in mammals. However, only a few have been reported in amphibians, such as Hyla nigrovittata, Xenopus laevis, and Rana catesbeiana, with none reported in urodele amphibians like newts and salamanders. Here, a CCK called CCK-TV was identified and characterized from the skin of the salamander Tylototriton verrucosus. This CCK contained an amino acid sequence of DYMGWMDF-NH2 as seen in other CCKs. A cDNA encoding the CCK precursor containing 129 amino acid residues was cloned from the cDNA library of T. verrucosus skin. The CCK-TV had the potential to induce the contraction of smooth muscle strips isolated from porcine gallbladder, eliciting contraction at a concentration of 5.0 x 10⁻¹¹ mol/L and inducing maximal contraction at a concentration of 2.0 x 10⁻⁶ mol/L. The EC50 was 13.6 nmol/L. To the best of our knowledge, this is the first report to identify the presence of a CCK in an urodele amphibian.
Indexed as
Identifiers
26018861PMC4790693W2236593239What OpenQuestion holds
Registered trials
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