Evidence map›Paper›PMID 26018511›Full record

ReviewJournal of pathology and translational medicine2015

Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia.

Nandor Gabor Than, Roberto Romero, Andrea Balogh, Eva Karpati, Salvatore Andrea Mastrolia, Orna Staretz-Chacham, Sinuhe Hahn, Offer Erez, Zoltan Papp, Chong Jai Kim

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of pathology and translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Nandor Gabor ThanPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI, USA ; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA ; Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences Budapest, Budapest, Hungary ; Maternity Private Department, Kutvolgyi Clinical Block, Semmelweis University, Budapest, Hangary ; First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Roberto RomeroPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI, USA.
Andrea BaloghPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI, USA ; Department of Immunology, Eotvos Lorand University, Budapest, Hungary.
Eva KarpatiInstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences Budapest, Budapest, Hungary ; Department of Immunology, Eotvos Lorand University, Budapest, Hungary.
Salvatore Andrea MastroliaDepartment of Obstetrics and Gynecology, Ben-Gurion University, Beer-Sheva, Israel ; Department of Obstetrics and Gynecology, University of Bari Aldo Moro, Bari, Italy.
Orna Staretz-ChachamDepartment of Neonatology, Ben-Gurion University, Beer-Sheva, Israel.
Sinuhe HahnDepartment of Biomedicine, University Hospital Basel, Basel, Switzerland.
Offer ErezPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI, USA ; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA ; Department of Obstetrics and Gynecology, Ben-Gurion University, Beer-Sheva, Israel.
Zoltan PappMaternity Private Department, Kutvolgyi Clinical Block, Semmelweis University, Budapest, Hangary.
Chong Jai KimPerinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI, USA ; Department of Pathology, Wayne State University, Detroit, MI, USA ; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
National Institutes of Health · USBen-Gurion University of the Negev · ILEunice Kennedy Shriver National Institute of Child Health and Human Development · USSemmelweis University · HUUniversity Hospital of Basel · CH

Funding

NICHD NIH HHS HHSN275201300006C
6 · The paper itself

Abstract

Galectins are an evolutionarily ancient and widely expressed family of lectins that have unique glycan-binding characteristics. They are pleiotropic regulators of key biological processes, such as cell growth, proliferation, differentiation, apoptosis, signal transduction, and pre-mRNA splicing, as well as homo- and heterotypic cell-cell and cell-extracellular matrix interactions. Galectins are also pivotal in immune responses since they regulate host-pathogen interactions, innate and adaptive immune responses, acute and chronic inflammation, and immune tolerance. Some galectins are also central to the regulation of angiogenesis, cell migration and invasion. Expression and functional data provide convincing evidence that, due to these functions, galectins play key roles in shared and unique pathways of normal embryonic and placental development as well as oncodevelopmental processes in tumorigenesis. Therefore, galectins may sometimes act as double-edged swords since they have beneficial but also harmful effects for the organism. Recent advances facilitate the use of galectins as biomarkers in obstetrical syndromes and in various malignancies, and their therapeutic applications are also under investigation. This review provides a general overview of galectins and a focused review of this lectin subfamily in the context of inflammation, infection and tumors of the female reproductive tract as well as in normal pregnancies and those complicated by the great obstetrical syndromes.

Indexed as

AlarminEpigenomicsMaternal-fetal interfaceNeoplasmsSex steroids

Identifiers

PMID26018511
PMCPMC4440931
OpenAlexW1874363102

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.