ArticleBMC musculoskeletal disorders2015
Screening for IgG4-type anti-nuclear antibodies in IgG4-related disease.
Article in BMC musculoskeletal disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Isolated pulmonary IgG4-related disease mimicking infection and malignancy: clinical features and a proposed diagnostic approach.Clinical rheumatology · 2026Article
- IgG4-related disease revealed by acute pancreatitis: A case report and literature review.Radiology case reports · 2025Article
- Unraveling the complexity of IgG4-related aortitis and periarteritis: from pathogenesis to clinical practice.Frontiers in immunology · 2025Review
- Immunoglobulin G4 in primary Sjögren's syndrome and IgG4-related disease - connections and dissimilarities.Frontiers in immunology · 2024Review
- Laboratory risk factors for coexistent primary biliary cholangitis in patients with Sjögren's syndrome: a retrospective study.BMC gastroenterology · 2023Article
- Pancreatic cancer, autoimmune or chronic pancreatitis, beyond tissue diagnosis: Collateral imaging and clinical characteristics may differentiate them.World journal of gastrointestinal oncology · 2023Review
- Acute liver injury and IgG4-related autoimmune pancreatitis following mRNA-based COVID-19 vaccination.Hepatology forum · 2022Article
- IgG4-related diseases of the digestive tract.Nature reviews. Gastroenterology & hepatology · 2022Review
- Identifying clinical subgroups in IgG4-related disease patients using cluster analysis and IgG4-RD composite score.Arthritis research & therapy · 2020Article
- Multiple Processes May Involve in the IgG4-RD Pathogenesis: An Integrative Study via Proteomic and Transcriptomic Analysis.Frontiers in immunology · 2020Article
- IgG4-related disease in endocrine practice.Archives of medical science : AMS · 2019Article
- Progression of immunoglobulin G4-related disease to systematic lupus erythematosus after gastric cancer surgery: A case report.Medicine · 2018Article
- IgG4-related disease coexisting with autoimmune haemolytic anaemia.BMJ case reports · 2018Article
- Diagnostic and treatment workup for IgG4-related disease.Expert review of clinical immunology · 2017Review
- IgG4-related membranous glomerulonephritis and generalized lymphadenopathy without pancreatitis: a case report.BMC nephrology · 2017Article
- Recent advances in understanding and managing IgG4-related disease.F1000Research · 2017Review
- Prevalence of antinuclear antibodies in healthy Lebanese subjects, 2008-2015: a cross-sectional study involving 10,814 subjects.Rheumatology international · 2016Article
- IgG4-related disease: current challenges and future prospects.Therapeutics and clinical risk management · 2016Review
- Overview of IgG4-Related Tubulointerstitial Nephritis and Its Mimickers.Journal of pathology and translational medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImmunoglobulin (Ig) G4-related disease (IgG4-RD) is characterized by elevated serum IgG4 and infiltration of IgG4(+) plasma cells into multiple organs. It is not known whether serum IgG4 is autoreactive in IgG4-RD.
methodsWe measured anti-nuclear antibody (ANA) in 19 IgG4-RD cases, determined IgG subclasses of the ANA, and compared them with those of other systemic autoimmune diseases (systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, and polymyositis), using subclass-based ANA test (indirect immunofluorescence).
results58 % of IgG4-RD cases were ANA-positive (cut-off: 1:40). Whereas their subclass of ANA was predominantly IgG2, we observed no IgG4-type ANA. In systemic autoimmune diseases, subclasses of ANA were mostly IgG1, 2, or 3, but IgG4-type ANA was very rarely detected. We also found several patients in whose serum ANA patterns differed among IgG subclasses, probably due to the difference of corresponding autoantigens.
conclusionsAlthough IgG4 is highly elevated in sera of IgG4-RD patients, their ANA do not include IgG4 subclass. These results offer new insight into the role of IgG4 and the pathogenesis of IgG4-RD, implying that each IgG subclass tends to cover its own spectrum of antigens, and IgG4 is not preferentially used to make ANA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.