ArticleJournal of applied oral science : revista FOB
Minimally traumatic alveolar ridge augmentation with a tunnel injectable thermo-sensitive alginate scaffold.
Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Developments of Thermosensitive Hydrogel for Maxillofacial Bone Regeneration.Small science · 2025Review
- Effects of Calcium Carbonate Microcapsules and Nanohydroxyapatite on Properties of Thermosensitive Chitosan/Collagen Hydrogels.Polymers · 2023Article
- Degradable hydrogel fibers encapsulate and deliver metformin and periodontal ligament stem cells for dental and periodontal regeneration.Journal of applied oral science : revista FOB · 2023Article
- Application of Nano-Inspired Scaffolds-Based Biopolymer Hydrogel for Bone and Periodontal Tissue Regeneration.Polymers · 2022Review
- Article
- Recent Advances on Magnetic Sensitive Hydrogels in Tissue Engineering.Frontiers in chemistry · 2020Review
- [Preparation of aspirin sustained-release microsphere and its in vitro releasing property].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- Nerve Cells Decide to Orient inside an Injectable Hydrogel with Minimal Structural Guidance.Nano letters · 2017Article
- Environment and bone regeneration: how biomaterials, host mediators and even bacterial products can boost bone cells towards better clinical outcomes.Journal of applied oral science : revista FOBArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledInjectable bone substitutes and techniques have been developed for use in minimally invasive procedures for bone augmentation.
objectiveTo develop a novel injectable thermo-sensitive alginate hydrogel (TSAH) as a scaffold to induce bone regeneration, using a minimally invasive tunnelling technique. MATERIAL AND
methodsAn injectable TSAH was prepared from a copolymer solution of 8.0 wt% Poly(N-isopropylacrylamide) (PNIPAAm) and 8.0 wt% AAlg-g-PNIPAAm. In vitro properties of the material, such as its microstructure and the sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2), were investigated. Then, with the subperiosteal tunnelling technique, this material, carrying rhBMP-2, was injected under the labial periosteum of the maxillary anterior alveolar ridge in a rabbit model. New bone formation was evaluated by means of X-ray, micro-computed tomography (micro-CT), fluorescence labelling, histological study, and immunohistochemistry study.
resultsThe material exhibited good injectability and thermo-irreversible properties. SEM showed an interconnected porous microstructure of the TSAH. The result of ALP activity indicated sustained delivery of BMP-2 from the TSAH from days 3 to 15. In a rabbit model, both TSAH and TSAH/rhBMP-2 induced alveolar ridge augmentation. The percentage of mineralised tissue in the TSAH/rhBMP-2 group (41.6 ± 3.79%) was significantly higher than in the TSAH group (31.3 ± 7.21%; p < 0.05). The density of the regenerating tissue was higher in the TSAH/rhBMP-2 group than in the other groups (TSAH group, positive control, blank control; p < 0.05).
conclusionsThe TSAH provided convenient handling properties for clinical application. To some extent, TSAH could induce ridge augmentation and mineral deposition, which can be enhanced when combined with rhBMP-2 for a minimally invasive tunnelling injection.
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