ArticleJournal of applied oral science : revista FOB
Differential expression of immunologic proteins in gingiva after socket preservation in mini pigs.
Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- The response of salivary proinflammatory biomarkers to tooth extraction in individuals with type II diabetes mellitus.BMC oral health · 2024Article
- [Structural characteristics of the deciduous teeth of Tibetan miniature pigs].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Environment and bone regeneration: how biomaterials, host mediators and even bacterial products can boost bone cells towards better clinical outcomes.Journal of applied oral science : revista FOBArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledDuring healing following tooth extraction, inflammation and the immune response within the extraction socket are related to bone resorption.
objectiveWe sought to identify how the alloplastic material used for socket preservation affects the immune responses and osteoclastic activity within extraction sockets. MATERIAL AND
methodsUsing a porcine model, we extracted teeth and grafted biphasic calcium phosphate into the extraction sockets. We then performed a peptide analysis with samples of gingival tissue from adjacent to the sockets and compared the extraction only (EO) and extraction with socket preservation (SP) groups. We also used real-time polymerase chain reaction (PCR) to evaluate the expression level of immunoglobulins, chemokines and other factors related to osteoclastogenesis. Differences between the groups were analyzed for statistical significance using paired t tests.
resultsLevels of IgM, IgG and IGL expression were higher in the EO group than in the SP group 1 week post-extraction, as were the levels of CCL3, CCL5, CXCL2, IFN-γ and TNF-α expression (p < 0.05). In addition, receptor activator of nuclear factor kappa-B ligand (RANKL) was also significantly upregulated in the EO group (p < 0.05), as were IL-1β, IL-6 and IL-8 (p < 0.05).
conclusionsThese results suggest that the beneficial effect of socket preservation can be explained by suppression of immune responses and inflammation.
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