Evidence map›Paper›PMID 26018199›Full record

ArticleJournal of child neurology2016

Visual Evoked Potentials as a Readout of Cortical Function in Infants With Tuberous Sclerosis Complex.

Kandice J Varcin, Charles A Nelson, Jordan Ko, Mustafa Sahin, Joyce Y Wu, Shafali Spurling Jeste

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Kandice J VarcinDivision of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Charles A NelsonDivision of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Graduate School of Education, Harvard University, Boston, MA, USA charles.nelson@childrens.harvard.edu.
Jordan KoSemel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Mustafa SahinF.M. Kirby Neurobiology Center, Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Joyce Y WuDivision of Pediatric Neurology, Mattel Children's Hospital at University of California, Los Angeles, CA, USA.
Shafali Spurling JesteSemel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Harvard University · USUniversity of California, Los Angeles · USBoston Children's Hospital · USMattel Children's Hospital · US

Funding

UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
High Frequency Oscillation as a Biomarker in Childhood EpilepsyR01NS082649 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WU, JOYCE Y · 2013 to 2017
$1.7M
NCRR NIH HHS UL1 RR033176NCRR NIH HHS UL1RR033176NINDS NIH HHS R01 NS082649
6 · The paper itself

Abstract

Tuberous sclerosis complex is an autosomal dominant genetic disorder that confers a high risk for neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. Studies have demonstrated specific delays in visual reception skills that may predict the development of autism spectrum disorder and intellectual disability. Based on evidence for alterations in the retinogeniculate pathway in animal models of tuberous sclerosis complex, we asked whether children with tuberous sclerosis complex demonstrate alterations in early visual processing that may undermine the development of higher-level visual behaviors. Pattern-reversal visual evoked potentials were recorded in infants with tuberous sclerosis complex (n = 16) and typically developing infants (n = 18) at 12 months of age. Infants with tuberous sclerosis complex demonstrated remarkably intact visual evoked potentials even within the context of intellectual disability and epilepsy. Infants with tuberous sclerosis complex show intact visual cortical processing, suggesting that delays in visually mediated behaviors in tuberous sclerosis complex may not be rooted in early visual processing deficits.

Indexed as

Evoked Potentials, VisualCerebral CortexElectroencephalographyFemaleHumansInfantLongitudinal StudiesMalePhotic StimulationTuberous SclerosisVisual Perceptionevent-related potentialsneurodevelopmental disorderstuberous sclerosis complexvisual evoked potentialsvisual processing

Identifiers

PMID26018199
PMCPMC5472095
OpenAlexW1957475160

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.