Evidence map›Paper›PMID 26018162›Full record

ArticleJournal of virology2015

Population Bottlenecks and Pathogen Extinction: "Make This Everyone's Mission to Mars, Including Yours".

Benjamin B Policicchio, Ivona Pandrea, Cristian Apetrei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Benjamin B PolicicchioCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Department of Infectious Diseases and Microbiology, Graduate School of Public Health, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ivona PandreaCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Department of Infectious Diseases and Microbiology, Graduate School of Public Health, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Cristian ApetreiCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Department of Infectious Diseases and Microbiology, Graduate School of Public Health, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA apetreic@pitt.edu.

Funding

Novel SIVsmm strains for analysis of mucosal transmission and vaccine protectionP01AI088564 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHAW, GEORGE M · 2010 to 2014
$12.7M
SIV Pathogenesis in African Green Monkeys and Pigtailed MacaquesR01HL117715 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VASILE PANDREA, IVONA · 2012 to 2021
$7.0M
Animal Model for SIV Infection ControlR01RR025781 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APETREI, CRISTIAN, VASILE PANDREA, IVONA · 2009 to 2010
$1.9M
Early Events and Determinants of Oral SIV Transmission in Infant Nonhuman PrimateR56DE023508 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APETREI, CRISTIAN · 2013 to 2013
$372k
NCRR NIH HHS R01 RR025781NHLBI NIH HHS R01 HL117715NIAID NIH HHS P01 AI088564NIDCR NIH HHS R56 DE023508
6 · The paper itself

Abstract

Kapusinszky et al. (J Virol 89:8152-8161, 2015, http://dx.doi.org/10.1128/JVI.00671-15) report that host population bottlenecks may result in pathogen extinction, which provides a compelling argument for an alternative approach to vaccination for the control of virus spread. By comparing the prevalence levels of three viral pathogens in two populations of African green monkeys (AGMs) (Chlorocebus sabaeus) from Africa and two Caribbean Islands, they convincingly show that a major host bottleneck resulted in the eradication of select pathogens from a given host.

Indexed as

Extinction, BiologicalAnimalsChlorocebus aethiops

Identifiers

PMID26018162
PMCPMC4524259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.