Evidence map›Paper›PMID 26018036›Full record

Trial reportPloS one2015

Randomized, Double-Blind, Placebo-Controlled Study on Decolonization Procedures for Methicillin-Resistant Staphylococcus aureus (MRSA) among HIV-Infected Adults.

Amy Weintrob, Ionut Bebu, Brian Agan, Alona Diem, Erica Johnson, Tahaniyat Lalani, Xun Wang, Mary Bavaro, Michael Ellis, Katrin Mende and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00631566 (Prospective Study on the Incidence, Predictors, and Characteristics of Methicillin-Resistant Staphylococcus Aureus Infections and a Randomized, Double-Blind Study on Decolonization Procedures for Prevention of MRSA Infections Among HIV-Infected Persons), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00631566 nacompletednot on this map

Prospective Study on the Incidence, Predictors, and Characteristics of Methicillin-Resistant Staphylococcus Aureus Infections and a Randomized, Double-Blind Study on Decolonization Procedures for Prevention of MRSA Infections Among HIV-Infected Persons

TypeinterventionalSponsorHenry M. Jackson Foundation for the Advancement of Military MedicineRan2007 to 2017Enrolled550ConditionsHIV Infections, Staphylococcal InfectionsArmsMupirocin (Bactroban) 2%, hexachlorophene (pHisoHex) 3%, Placebo
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Amy WeintrobInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America; Infectious Disease Clinic, Walter Reed National Military Medical Center, Bethesda, MD, United States of America.
Ionut BebuInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America.
Brian AganInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America.
Alona DiemInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America; Infectious Disease Clinic, Naval Medical Center San Diego, San Diego, CA, United States of America.
Erica JohnsonInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America; Infectious Disease Service, San Antonio Military Medical Center, San Antonio, TX, United States of America.
Tahaniyat LalaniInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America; Infectious Disease Clinic, Naval Medical Center, Portsmouth, VA, United States of America.
Xun WangInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America.
Mary BavaroInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America; Infectious Disease Clinic, Naval Medical Center San Diego, San Diego, CA, United States of America.
Michael EllisDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America.
Katrin MendeInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America; Infectious Disease Service, San Antonio Military Medical Center, San Antonio, TX, United States of America.
Nancy Crum-CianfloneInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America; Infectious Disease Clinic, Naval Medical Center San Diego, San Diego, CA, United States of America.
Uniformed Services University of the Health Sciences · USNaval Medical Center San Diego · USSan Antonio Military Medical Center · USWalter Reed National Military Medical Center · US

Funding

DATA CENTER FOR EPIDEMIOLOGIC INVESTIGATIONS OF HIVN01AI005072 · NIAID · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MCKINLAY, SONJA M · 1990 to 1994
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NIAID NIH HHS Y01 AI005072NIAID NIH HHS Y1-AI-5072
6 · The paper itself

Abstract

backgroundHIV-infected persons have increased risk of MRSA colonization and skin and soft-tissue infections (SSTI). However, no large clinical trial has examined the utility of decolonization procedures in reducing MRSA colonization or infection among community-dwelling HIV-infected persons.

methods550 HIV-infected adults at four geographically diverse US military HIV clinics were prospectively screened for MRSA colonization at five body locations every 6 months during a 2-year period. Those colonized were randomized in a double-blind fashion to nasal mupirocin (Bactroban) twice daily and hexachlorophene (pHisoHex) soaps daily for 7 days compared to placeboes similar in appearance but without specific antibacterial activity. The primary endpoint was MRSA colonization at 6-months post-randomization; secondary endpoints were time to MRSA clearance, subsequent MRSA infections/SSTI, and predictors for MRSA clearance at the 6-month time point.

resultsForty-nine (9%) HIV-infected persons were MRSA colonized and randomized. Among those with 6-month colonization data (80% of those randomized), 67% were negative for MRSA colonization in both groups (p = 1.0). Analyses accounting for missing 6-month data showed no significant differences could have been achieved. In the multivariate adjusted models, randomization group was not associated with 6-month MRSA clearance. The median time to MRSA clearance was similar in the treatment vs. placebo groups (1.4 vs. 1.8 months, p = 0.35). There was no difference on subsequent development of MRSA infections/SSTI (p = 0.89). In a multivariable model, treatment group, demographics, and HIV-specific factors were not predictive of MRSA clearance at the 6-month time point.

conclusionA one-week decolonization procedure had no effect on MRSA colonization at the 6-month time point or subsequent infection rates among community-dwelling HIV-infected persons. More aggressive or novel interventions may be needed to reduce the burden of MRSA in this population.

trial registrationClinicalTrials.gov NCT00631566.

Indexed as

AdultAnti-Bacterial AgentsDouble-Blind MethodFemaleHexachloropheneHIV InfectionsHumansMaleMethicillin-Resistant Staphylococcus aureusMiddle AgedMupirocinProspective StudiesStaphylococcal InfectionsAnti-Bacterial AgentsHexachloropheneMupirocin

Identifiers

PMID26018036
PMCPMC4446345
OpenAlexW1512939585

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.