ReviewThe Journal of physiology2015
Nicotine and the adolescent brain.
Review in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 319 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
319 citing papers in PubMed, 7 syntheses or guidelines pooled it, 532 citations in OpenAlex.
- Tobacco and cannabis use in the young 'Not in Employment, Education or Training' population: A systematic review and meta-analysis.Addiction (Abingdon, England) · 2026Pooled it
- Impact of e-cigarette advertising, promotion, and sponsorship on cognition and behavior: a systematic review of public responses.BMC health services research · 2025Pooled it
- Treatment of Nicotine Use in Adolescents Under 18 Years of Age: An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2025Guideline
- Association between e-cigarette use and COVID-19 diagnosis: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Peer Influence and Use of Electronic Cigarettes among Adolescents and Young Adults: A Meta-Analysis of Prospective Studies.Asian Pacific journal of cancer prevention : APJCP · 2025Pooled it
- A Systematic Review and Meta-analysis of School-Based Preventive Interventions Targeting E-Cigarette Use Among Adolescents.Prevention science : the official journal of the Society for Prevention Research · 2024Pooled it
- Chronic tobacco smoking and neurocognitive impairments in adolescents and young adults: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Partial Nicotine Reduction and E-Cigarette Users' Puffing Behaviors Among Adults Aged 21 to 35 Years: A Randomized Crossover Clinical Trial.JAMA network open · 2024Trial
- Psychosocial Correlates of Exclusive and Dual Nicotine Use among Adolescents in a Context of E-Cigarette Sales Prohibition.Journal of community health · 2026Article
- Impact of E-Liquids on Phagocytosis, Escape and Invasion ofPathogens (Basel, Switzerland) · 2026Article
- Nicotine in Neurodegenerative and Neuropsychiatric Disorders: Mechanisms and Clinical Evidence.Neurochemical research · 2026Review
- A Qualitative Comparative Analysis of State Flavored E-Cigarette Policy Implementation and E-Cigarette Use.American journal of preventive medicine · 2026Article
- Relational Victimization, Depressive Symptoms, and E-cigarette Use Intentions Among Adolescents: A Parallel Process Growth Curve Model.Research on child and adolescent psychopathology · 2026Article
- Early life nicotine vapor exposure increases nicotine vapor seeking in adult male rats.Psychopharmacology · 2026Article
- Distinct Motives for Tobacco Use Among Rural Versus Urban Residing Sexual Minority Young Adults in Oklahoma and Surrounding States.Substance use & addiction journal · 2026Article
- A Metaverse Program to Prevent E-Cigarette Use Among Adolescents: Pilot Mixed Methods Study.JMIR mHealth and uHealth · 2026Article
- Why Adolescents Choose to Stop or Never Start Vaping: Evidence From South Africa.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Dentate Gyrus ERK1/2-BDNF Signaling is Required for the Antidepressant Effect of Microglial Stimulation in a Male Mouse Model of Depression Induced by Adolescent Nicotine Exposure.Neurochemical research · 2026Article
- Abnormal effective connectivity of default mode network subsystems affects depressive symptoms and sleep disturbances in adolescents with internet gaming disorder.BMC psychiatry · 2026Article
- Pathways between parental monitoring and adolescent e-cigarette use: The role of parent-child internalizing and externalizing discrepancies in a predominately Hispanic/Latino(a) sample.Translational issues in psychological science · 2026Article
259 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adolescence encompasses a sensitive developmental period of enhanced clinical vulnerability to nicotine, tobacco, and e-cigarettes. While there are sociocultural influences, data at preclinical and clinical levels indicate that this adolescent sensitivity has strong neurobiological underpinnings. Although definitions of adolescence vary, the hallmark of this period is a profound reorganization of brain regions necessary for mature cognitive and executive function, working memory, reward processing, emotional regulation, and motivated behavior. Regulating critical facets of brain maturation are nicotinic acetylcholine receptors (nAChRs). However, perturbations of cholinergic systems during this time with nicotine, via tobacco or e-cigarettes, have unique consequences on adolescent development. In this review, we highlight recent clinical and preclinical data examining the adolescent brain's distinct neurobiology and unique sensitivity to nicotine. First, we discuss what defines adolescence before reviewing normative structural and neurochemical alterations that persist until early adulthood, with an emphasis on dopaminergic systems. We review how acute exposure to nicotine impacts brain development and how drug responses differ from those seen in adults. Finally, we discuss the persistent alterations in neuronal signaling and cognitive function that result from chronic nicotine exposure, while highlighting a low dose, semi-chronic exposure paradigm that may better model adolescent tobacco use. We argue that nicotine exposure, increasingly occurring as a result of e-cigarette use, may induce epigenetic changes that sensitize the brain to other drugs and prime it for future substance abuse.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.