ArticleAmerican journal of physiology. Renal physiology2015
Role of the brain stem in tibial inhibition of the micturition reflex in cats.
Article in American journal of physiology. Renal physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Article
- Bladder underactivity induced by prolonged pudendal afferent activity in cats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Prolonged nonobstructive urinary retention induced by tibial nerve stimulation in cats.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Spinal interneuronal mechanisms underlying pudendal and tibial neuromodulation of bladder function in cats.Experimental neurology · 2018Article
- Frequency Dependent Tibial Neuromodulation of Bladder Underactivity and Overactivity in Cats.Neuromodulation : journal of the International Neuromodulation Society · 2018Article
- Bladder underactivity after prolonged stimulation of somatic afferent axons in the tibial nerve in cats.Neurourology and urodynamics · 2018Article
- Saphenous nerve stimulation normalizes bladder underactivity induced by tibial nerve stimulation in cats.American journal of physiology. Renal physiology · 2018Article
- Age-Related Changes in Neuromodulatory Control of Bladder Micturition Contractions Originating in the Skin.Frontiers in neuroscience · 2018Article
- An excitatory reflex from the superficial peroneal nerve to the bladder in cats.American journal of physiology. Renal physiology · 2017Article
- Urinary incontinence in women.Nature reviews. Disease primers · 2017Review
- Sacral neuromodulation of nociceptive bladder overactivity in cats.Neurourology and urodynamics · 2017Article
- Sex difference in the contribution of GABAAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Role of cannabinoid receptor type 1 in tibial and pudendal neuromodulation of bladder overactivity in cats.American journal of physiology. Renal physiology · 2017Article
- Effectiveness of percutaneous tibial nerve stimulation in the treatment of overactive bladder syndrome.Research and reports in urology · 2017Review
- Contribution of GABAA, Glycine, and Opioid Receptors to Sacral Neuromodulation of Bladder Overactivity in Cats.The Journal of pharmacology and experimental therapeutics · 2016Article
- Role of µ, κ, and δ opioid receptors in tibial inhibition of bladder overactivity in cats.The Journal of pharmacology and experimental therapeutics · 2015Article
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9 authors at 1 institution in 2 countries.
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Abstract
This study examined the role of the brain stem in inhibition of bladder reflexes induced by tibial nerve stimulation (TNS) in α-chloralose-anesthetized decerebrate cats. Repeated cystometrograms (CMGs) were performed by infusing saline or 0.25% acetic acid (AA) to elicit normal or overactive bladder reflexes, respectively. TNS (5 or 30 Hz) at three times the threshold (3T) intensity for inducing toe movement was applied for 30 min between CMGs to induce post-TNS inhibition or applied during the CMGs to induce acute TNS inhibition. Inhibition was evident as an increase in bladder capacity without a change in amplitude of bladder contractions. TNS applied for 30 min between saline CMGs elicited prolonged (>2 h) poststimulation inhibition that significantly (P < 0.05) increased bladder capacity to 30-60% above control; however, TNS did not produce this effect during AA irritation. TNS applied during CMGs at 5 Hz but not 30 Hz significantly (P < 0.01) increased bladder capacity to 127.3 ± 6.1% of saline control or 187.6 ± 5.0% of AA control. During AA irritation, naloxone (an opioid receptor antagonist) administered intravenously (1 mg/kg) or directly to the surface of the rostral brain stem (300-900 μg) eliminated acute TNS inhibition and significantly (P < 0.05) reduced bladder capacity to 62.8 ± 22.6% (intravenously) or 47.6 ± 25.5% (brain stem application). Results of this and previous studies indicate 1) forebrain circuitry rostral to the pons is not essential for TNS inhibition; and 2) opioid receptors in the brain stem have a critical role in TNS inhibition of overactive bladder reflexes but are not involved in inhibition of normal bladder reflexes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.