ArticleBioconjugate chemistry2015
Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression.
Article in Bioconjugate chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed.
- Visualization of a Bruton's Tyrosine Kinase Inhibitor Using Fluorescence and Raman Microscopy.Analytical chemistry · 2026Article
- Modular Vinyl Phosphonamidates for Cysteine-Directed Protein Targeting.Journal of the American Chemical Society · 2026Article
- Fluorescent PSMA-Targeted Radiotheranostic Compounds for Multiscale Imaging.Bioconjugate chemistry · 2025Article
- Building a Medicinal Chemistry Framework for Bioorthogonal Probes.ACS central science · 2025Article
- Investigation of Proteome-Tetrazine Reactivity for a Highly Selective Tetrazine Ligation in Live Cells.ACS central science · 2025Article
- Method To Diversify Cyanine Chromophore Functionality Enables Improved Biomolecule Tracking and Intracellular Imaging.Journal of the American Chemical Society · 2023Article
- OregonFluor enables quantitative intracellular paired agent imaging to assess drug target availability in live cells and tissues.Nature chemistry · 2023Article
- Tumor-Cell-Specific Targeting of Ibrutinib: Introducing Electrostatic Antibody-Inhibitor Conjugates (AiCs).Angewandte Chemie (International ed. in English) · 2022Article
- Fluorescent kinase inhibitors as probes in cancer.Chemical Society reviews · 2021Review
- SMALL MOLECULE IMAGING AGENT FOR MUTANT KRAS G12C.Advanced therapeutics · 2021Article
- 3D Whole-Brain Imaging Approaches to Study Brain Tumors.Cancers · 2021Review
- Quantification of Cellular Drug Biodistribution Addresses Challenges in EvaluatingAdvanced therapeutics · 2021Article
- A Cleavable CJournal of the American Chemical Society · 2020Article
- Recent advances in construction of small molecule-based fluorophore-drug conjugates.Journal of pharmaceutical analysis · 2020Review
- Understanding the in vivo Fate of Advanced Materials by Imaging.Advanced functional materials · 2020Article
- Single-Cell Intravital Microscopy of Trastuzumab Quantifies Heterogeneous in vivo Kinetics.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2020Article
- Imaging of Tie2 with a Fluorescently Labeled Small Molecule Affinity Ligand.ACS chemical biology · 2020Article
- Synthesis of a dihalogenated pyridinyl silicon rhodamine for mitochondrial imaging by a halogen dance rearrangement.Beilstein journal of organic chemistry · 2019Article
- A new approach to silicon rhodamines by Suzuki-Miyaura coupling - scope and limitations.Beilstein journal of organic chemistry · 2019Article
- Rhenium (I) Complexes as Probes for Prokaryotic and Fungal Cells by Fluorescence Microscopy: Do Ligands Matter?Frontiers in chemistry · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Bruton's tyrosine kinase (Btk) is intricately involved in anti-apoptotic signaling pathways in cancer and in regulating innate immune response. A number of Btk inhibitors are in development for use in treating B-cell malignancies and certain immunologic diseases. To develop robust companion imaging diagnostics for in vivo use, we set out to explore the effects of red wavelength fluorochrome modifications of two highly potent irreversible Btk inhibitors, Ibrutinib and AVL-292. Surprisingly, we found that subtle chemical differences in the fluorochrome had considerable effects on target localization. Based on iterative designs, we developed a single optimized version with superb in vivo imaging characteristics enabling single cell Btk imaging in vivo. This agent (Ibrutinib-SiR-COOH) is expected to be a valuable chemical tool in deciphering Btk biology in cancer and host cells in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.