Evidence map›Paper›PMID 26017742›Full record

Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2016

The effect of subacromial injections of autologous conditioned plasma versus cortisone for the treatment of symptomatic partial rotator cuff tears.

Lutz von Wehren, Fabian Blanke, Atanas Todorov, Patricia Heisterbach, Jannis Sailer, Martin Majewski

Abstract readClinical TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 6 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 6 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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  5. Platelet-rich plasma in tendon-related disorders: results and indications.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Lutz von WehrenOrthopädie, Universitätsspital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.
Fabian BlankeKlinik für Sportorthopädie und arthroskopische Chirurgie, Orthopädische Fachkliniken der Hessingstiftung, Hessingstrasse 17, 86199, Augsburg, Germany.
Atanas TodorovOrthopädie, Universitätsspital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.
Patricia HeisterbachOrthopädie, Universitätsspital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.
Jannis SailerOrthopädie, Universitätsspital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.
Martin MajewskiOrthopädie, Universitätsspital Basel, Spitalstrasse 21, 4031, Basel, Switzerland. martin.majewski@usb.ch.
University Hospital of Basel · CHHess (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRotator cuff tears are one of the most common causes of shoulder malfunction and pain, which lead to a significant reduction in the quality of life. This present study investigated the effects of subacromial platelet-rich plasma injections [i.e. autologous conditioned plasma (ACP) injections] as compared to standard subacromial cortisone injection therapy in 50 patients with partial rotator cuff tears.

methodsBefore injection, and 6 weeks, 12 weeks and 6 months thereafter, the patients were assessed by the Constant-Murley score (CMS), the American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form (ASES), the simple shoulder test (SST) and a pain visual analogue scale (VAS). An MRI was also performed before and 6 months after injection.

resultsBoth patient groups had statistically significant better shoulder score outcomes over time. ASES, SST and CMS outcomes after 12 versus 6 weeks were better in the ACP group as compared to the cortisone group. VAS, ASES and CMS outcomes after 12 weeks versus baseline in the ACP group were better as compared to the cortisone group. There was a statistically significant difference between ACP group and cortisone group 12 weeks after injection regarding VAS, ASES, SST and CMS in favour of the ACP group. The MRI showed an improvement in grade of tendinopathy in both groups, however, without statistically significant differences between the two groups.

conclusionCompared with cortisone injections, ACP injections show earlier benefit as compared to cortisone injections although a statistically significant difference after 6 months could not be found. Therefore, subacromial ACP injections are a good alternative to subacromial cortisone injections, especially in patients with contraindication to cortisone. LEVEL OF EVIDENCE: Therapeutic study, Level III.

Indexed as

AdultAgedAnti-Inflammatory AgentsArthroscopyBlood Component TransfusionCortisoneFemaleHumansInjectionsInjections, Intra-ArticularMaleMiddle AgedPain MeasurementPlatelet-Rich PlasmaQuality of LifeRotator CuffAnti-Inflammatory AgentsCortisoneAutologous conditioned plasmaPlatelet-rich plasmaRotator cuffShoulder painSubacromial impingement syndrome

Identifiers

PMID26017742
OpenAlexW1600563461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.