ArticleNature communications2015
A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Mendelian randomization studies on coronary artery disease: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids.Cardiovascular diabetology · 2016Pooled it
- A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics.Cardiovascular diabetology · 2016Trial
- Elucidating the causal role of age of menarche, adiposity, lipid fractions, and blood pressure upon cardiovascular disease: a multivariable Mendelian randomization study.Journal of human hypertension · 2025Article
- Diabetes, glycaemic traits and cardiovascular disease in females and males: Observational and Mendelian randomisation analyses in the UK Biobank.Diabetes, obesity & metabolism · 2025Observational
- A systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemia.Journal of diabetes investigation · 2025Article
- Investigating whether smoking and alcohol behaviours influence risk of type 2 diabetes using a Mendelian randomisation study.Scientific reports · 2025Article
- Development and validation of nomograms for predicting cardiovascular disease risk in patients with prediabetes and diabetes.Scientific reports · 2024Article
- Genome Variability for the Development of Coronary Heart Disease in Type 2 Diabetes Mellitus: A Bibliometric Analysis.Journal of multidisciplinary healthcare · 2024Article
- Mendelian randomization analyses clarify the effects of height on cardiovascular diseases.PloS one · 2024Article
- Disentangling Dual Threats: Premature Coronary Artery Disease and Early-Onset Type 2 Diabetes Mellitus in South Asians.Journal of the Endocrine Society · 2023Review
- Causal associations between type 1 diabetes mellitus and cardiovascular diseases: a Mendelian randomization study.Cardiovascular diabetology · 2023Article
- Article
- Polygenic risk for type 2 diabetes, lifestyle, metabolic health, and cardiovascular disease: a prospective UK Biobank study.Cardiovascular diabetology · 2022Article
- Interpreting Mendelian-randomization estimates of the effects of categorical exposures such as disease status and educational attainment.International journal of epidemiology · 2022Article
- Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes.Diabetologia · 2022Article
- Robust estimates of heritable coronary disease risk in individuals with type 2 diabetes.Genetic epidemiology · 2022Article
- Management of diabetic foot ulcers and the challenging points: An endocrine view.World journal of diabetes · 2022Review
- Systolic blood pressure as the mediator of the effect of early menarche on the risk of coronary artery disease: A Mendelian randomization study.Frontiers in cardiovascular medicine · 2022Article
- Causal effects of genetically predicted type 2 diabetes mellitus on blood lipid profiles and concentration of particle-size-determined lipoprotein subclasses: A two-sample Mendelian randomization study.Frontiers in cardiovascular medicine · 2022Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
In observational studies, type-2 diabetes (T2D) is associated with an increased risk of coronary heart disease (CHD), yet interventional trials have shown no clear effect of glucose-lowering on CHD. Confounding may have therefore influenced these observational estimates. Here we use Mendelian randomization to obtain unconfounded estimates of the influence of T2D and fasting glucose (FG) on CHD risk. Using multiple genetic variants associated with T2D and FG, we find that risk of T2D increases CHD risk (odds ratio (OR)=1.11 (1.05-1.17), per unit increase in odds of T2D, P=8.8 × 10(-5); using data from 34,840/114,981 T2D cases/controls and 63,746/130,681 CHD cases/controls). FG in non-diabetic individuals tends to increase CHD risk (OR=1.15 (1.00-1.32), per mmol·per l, P=0.05; 133,010 non-diabetic individuals and 63,746/130,681 CHD cases/controls). These findings provide evidence supporting a causal relationship between T2D and CHD and suggest that long-term trials may be required to discern the effects of T2D therapies on CHD risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.