ArticleBritish journal of clinical pharmacology2015
Liver transplant associated with paracetamol overdose: results from the seven-country SALT study.
Article in British journal of clinical pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Oral paracetamol (acetaminophen) for cancer pain.The Cochrane database of systematic reviews · 2017Pooled it
- Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults.The Cochrane database of systematic reviews · 2016Pooled it
- Paracetamol (acetaminophen) for acute treatment of episodic tension-type headache in adults.The Cochrane database of systematic reviews · 2016Pooled it
- Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy).Toxicological sciences : an official journal of the Society of Toxicology · 2024Trial
- Medication adherence in adolescents: physiological, psychosocial, and clinical perspectives.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Enhancing Salt Tolerance and Bioactivity inACS omega · 2026Article
- CpG-oligodeoxynucleotides challenged macrophages ameliorate acetaminophen induced liver injury by activating TLR9/IRG1/itaconate metabolic pathway.Molecular medicine (Cambridge, Mass.) · 2025Article
- Gardenia jasminoides extract mitigates acetaminophen-induced liver damage in mice.BMC complementary medicine and therapies · 2024Article
- Elderly mice with history of acetaminophen intoxication display worsened cognitive impairment and persistent elevation of astrocyte and microglia burden.Scientific reports · 2024Article
- The Role of Carbamoyl Phosphate Synthetase 1 as a Prognostic Biomarker in Patients With Acetaminophen-induced Acute Liver Failure.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023Article
- LateClinical case reports · 2023Article
- Exploring public knowledge and perceptions regarding per os OTC pain-relieving medications: the case of paracetamol (acetaminophen).Journal of pharmaceutical policy and practice · 2023Article
- Calcitriol Protects against Acetaminophen-Induced Hepatotoxicity in Mice.Biomedicines · 2023Article
- Variation in the Care of Acute Liver Failure: A Survey of Intensive Care Professionals.GE Portuguese journal of gastroenterology · 2022Article
- Potential deleterious effects of paracetamol dose regime used in Nigeria versus that of the United States of America.Toxicology reports · 2022Review
- Is There an Increased Risk of Hepatotoxicity with Metamizole? A Comparative Cohort Study in Incident Users.Drug safety · 2021Article
- Does Ibuprofen Worsen COVID-19?Drug safety · 2020Article
- Liver injury induced by paracetamol and challenges associated with intentional and unintentional use.World journal of hepatology · 2020Review
- Efficacy and safety of modified-release paracetamol for acute and chronic pain: a systematic review protocol.BMJ open · 2019Article
- Hepatotoxicity risk factors and acetaminophen dose adjustment, do prescribers give this issue adequate consideration? A French university hospital study.European journal of clinical pharmacology · 2019Article
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAcute drug overdose, especially with paracetamol, may cause acute liver failure leading to registration for transplantation (ALFT). Population statistics and between-country differences for ALFT related to overdose have been poorly described. The aim of the present study was to evaluate overdose ALFT in the multi-country Study of Acute Liver Transplantation (SALT).
methodsAll adult overdose-related ALFT, with or without suicidal intent, in France, Greece, Ireland, Italy, the Netherlands, Portugal and the UK between 2005 and 2007 were identified from liver transplant registries and hospital records. These were compared with whole-country and per capita use of paracetamol.
resultsSix hundred cases of ALFT were identified in 52 of 57 eligible transplant centres, of which 114 involved overdose (72 intentional, 10 non-intentional, 32 uncertain). Overdose represented 20% of all-cause ALFT: Ireland 52%, UK 28%, France 18%, the Netherlands 8%, and Italy 1%. Overdose ALFT were mostly females (61%), mean age 33.6 ± 10.9 years. A total of 111 (97%) of the overdoses involved paracetamol. Event rates ranged from one ALFT for 20.7 tons of paracetamol in Ireland, to one for 1074 tons in Italy and one case in 60 million inhabitants over 3 years in Italy to one case in 286 000 inhabitants per year in Ireland. Per-country event rates for non-overdose ALFT exposed to paracetamol were between 2.5 and 4.0 per million treatment-years sold.
conclusionsParacetamol overdose was found to represent one-sixth of all-cause ALFT. There was a 50-fold difference in Europe in the rates of paracetamol overdose ALFT, and a 200-fold difference per million inhabitants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.