ReviewCurrent osteoporosis reports2015
The Role of B-Vitamins in Bone Health and Disease in Older Adults.
Review in Current osteoporosis reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Folate and global health umbrella review series, part 1: methodological framework and syntheses on anaemia and neural tube defects.Journal of global health · 2026Pooled it
- B vitamins and bone health: a meta-analysis with trial sequential analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Pooled it
- The Use of Antidepressive Agents and Bone Mineral Density in Women: A Meta-Analysis.International journal of environmental research and public health · 2018Pooled it
- Bone density and depressive disorder: a meta-analysis.Brain and behavior · 2016Pooled it
- Effect of Combination Folic Acid, Vitamin BJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Trial
- The role of B-vitamin intake, B-vitamin-rich dietary patterns, the B-vitamin deficiency index in bone mineral density among school-aged children.Pediatric research · 2026Article
- Does the Nutrient Adequacy Ratio (NAR) Predict Metabolic Profile and Glycemic Status Among the Obese Population?Nutrition and metabolic insights · 2025Article
- Linking the relationship between dietary folic acid intake and risk of osteoporosis among middle-aged and older people: A nationwide population-based study.Food science & nutrition · 2024Article
- Associations of serum vitamin B12 and its biomarkers with musculoskeletal health in middle-aged and older adults.Frontiers in endocrinology · 2024Article
- Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional study.Journal of orthopaedic surgery and research · 2023Article
- Association Between the Dietary Inflammatory Index and the Risk of Fracture in Chinese Adults: Longitudinal Study.JMIR public health and surveillance · 2023Article
- Effect of Vitamin B6 on Osteoporosis Fracture.Journal of bone metabolism · 2023Article
- Therapeutic Potential of Zeolites/Vitamin B12 Nanocomposite on Complete Freund's Adjuvant-Induced Arthritis as a Bone Disorder: In Vivo Study and Bio-Molecular Investigations.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients.Therapeutic advances in musculoskeletal disease · 2023Review
- Risk of hip fracture in meat-eaters, pescatarians, and vegetarians: results from the UK Women's Cohort Study.BMC medicine · 2022Article
- Do patients with gastroesophageal reflux disease exhibit compromised bone quality prior to proton pump inhibitor therapy?Bone reports · 2021Article
- Hyperhomocysteinemia is Associated with Inflammation, Bone Resorption, Vitamin B12 and Folate Deficiency and MTHFR C677T Polymorphism in Postmenopausal Women with Decreased Bone Mineral Density.International journal of environmental research and public health · 2020Article
- Proton pump inhibitors and fracture: they impair bone quality and increase fall risk?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The risk of osteoporosis and bone fractures increases with age. Several other factors are also related to bone disease including gender, race/ethnicity, physical activity, alcohol, smoking, estrogen, and calcium and vitamin D. B-vitamins (folate, B12, and B6) are also emerging dietary factors related to bone health, both individually and through their action on influencing total plasma homocysteine concentrations (tHcy). The primary objective of this review is to summarize the available data on B-vitamins and bone health, highlighting clinical trials and observational data. In populations without folic acid fortification, the totality of evidence suggests that elevated tHcy has a small but significant association with bone fracture risk and bone quality but not on bone mineral density (BMD) or bone turnover biomarkers. Very little supportive evidence exists for a direct role of folate for either BMD or fracture risk; however, the data available are quite limited. Meta-analyses and some cross-sectional and cohort studies suggest a small but significant role of vitamin B12 status on risk of fracture but not on BMD. The mechanism by which tHcy and B12 may influence bone health is not well characterized but may be through modulation of collagen cross-linking or through altering osteoclasts or osteoblasts. Much more data are needed-particularly the role that each vitamin directly has on bone, or whether the vitamins only exert their effect though tHcy concentrations. Nevertheless, consistent findings across different populations with different study designs suggest a role for tHcy and B12 in reducing fracture risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.