ArticleBMC plant biology2015
The maize cytochrome P450 CYP79A61 produces phenylacetaldoxime and indole-3-acetaldoxime in heterologous systems and might contribute to plant defense and auxin formation.
Article in BMC plant biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 74 citations in OpenAlex.
- Aldoximes serve as auxin precursors and repress phenylpropanoid metabolism in tomato.bioRxiv : the preprint server for biology · 2026Article
- The IAOx-Dependent IAA Biosynthesis Pathway: Acquired Insights, Paradigm Shifts, and Unresolved Questions.Plants (Basel, Switzerland) · 2026Review
- The auxin gatekeepers: Evolution and diversification of the YUCCA family.The Plant journal : for cell and molecular biology · 2025Article
- The CYP71A, NIT, AMI, and IAMH gene families are dispensable for indole-3-acetaldoxime-mediated auxin biosynthesis in Arabidopsis.The Plant cell · 2025Article
- Unveiling the Potential Role of Dhurrin in Sorghum During Infection by the Head Smut PathogenPlants (Basel, Switzerland) · 2025Article
- Identification of MsCYP79 and MsCYP83 gene families and its response to mechanical damage in Medicago sativa L.PloS one · 2025Article
- Robotic mechanical wounding is sufficient to induce phenylacetaldoxime accumulation inPlant signaling & behavior · 2024Article
- Aldoxime dehydratases: production, immobilization, and use in multistep processes.Applied microbiology and biotechnology · 2024Review
- A Convenient Route to Large-Scale Chemical Synthesis ofACS omega · 2024Article
- Integrated pathway mining and selection of an artificial CYP79-mediated bypass to improve benzylisoquinoline alkaloid biosynthesis.Microbial cell factories · 2024Article
- Cytochrome P450 Gene Families: Role in Plant Secondary Metabolites Production and Plant Defense.Journal of xenobiotics · 2023Review
- Novel insights into maize (Zea mays) development and organogenesis for agricultural optimization.Planta · 2023Review
- Do Opposites Attract? Auxin-Abscisic Acid Crosstalk: New Perspectives.International journal of molecular sciences · 2023Review
- Occurrence, Function, and Biosynthesis of the Natural Auxin Phenylacetic Acid (PAA) in Plants.Plants (Basel, Switzerland) · 2023Review
- Comprehensive and evolutionary analysis ofFrontiers in plant science · 2023Article
- Metabolic link between auxin production and specialized metabolites in Sorghum bicolor.Journal of experimental botany · 2023Article
- Aldoximes are precursors of auxins in Arabidopsis and maize.The New phytologist · 2021Article
- Identification and Validation of Genomic Regions Associated With Charcoal Rot Resistance in Tropical Maize by Genome-Wide Association and Linkage Mapping.Frontiers in plant science · 2021Article
- Role of Cytochrome P450 Enzymes in Plant Stress Response.Antioxidants (Basel, Switzerland) · 2020Review
- Comparative functional genomics analysis of cytochrome P450 gene superfamily in wheat and maize.BMC plant biology · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlants produce a group of aldoxime metabolites that are well known as volatiles and as intermediates in cyanogenic glycoside and glucosinolate biosynthesis in particular plant families. Recently it has been demonstrated that aldoximes can also accumulate as part of direct plant defense in poplar. Cytochrome P450 enzymes of the CYP79 family were shown to be responsible for the formation of aldoximes from their amino acid precursors.
resultsHere we describe the identification and characterization of maize CYP79A61 which was heterologously expressed in yeast and Nicotiana benthamiana and shown to catalyze the formation of (E/Z)-phenylacetaldoxime and (E/Z)-indole-3-acetaldoxime from L-phenylalanine and L-tryptophan, respectively. Simulated herbivory on maize leaves resulted in an increased CYP79A61 transcript accumulation and in elevated levels of L-phenylalanine and (E/Z)-phenylacetaldoxime. Although L-tryptophan levels were also increased after the treatment, (E/Z)-indole-3-acetaldoxime could not be detected in the damaged leaves. However, simulated herbivory caused a significant increase in auxin concentration.
conclusionsOur data suggest that CYP79A61 might contribute to the formation of (E/Z)-phenylacetaldoxime in maize. Since aldoximes have been described as toxic compounds for insect herbivores and pathogens, the increased accumulation of (E/Z)-phenylacetaldoxime after simulated herbivory indicates that this compound plays a role in plant defense. In addition, it is conceivable that (E/Z)-indole-3-acetaldoxime produced by recombinant CYP79A61 could be further converted into the plant hormone indole-3-acetic acid after herbivore feeding in maize.
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