ArticleScientific reports2015
The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 77 citations in OpenAlex.
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- Tracing human genetic histories and natural selection with precise local ancestry inference.Nature communications · 2025Article
- Bi-allelic PRRT2 variants may predispose to Self-limited Familial Infantile Epilepsy.European journal of human genetics : EJHG · 2024Article
- Clinical phenotyping and genetic diagnosis of a large cohort of Sudanese families with hereditary spinocerebellar degenerations.European journal of human genetics : EJHG · 2024Article
- Genomic and physiological mechanisms of high-altitude adaptation in Ethiopian highlanders: a comparative perspective.Frontiers in genetics · 2024Review
- Factors associated with completeness in documentation of diagnostic work-up and treatment in patients with breast cancer in Sudan.Ecancermedicalscience · 2023Article
- Social stratification without genetic differentiation at the site of Kulubnarti in Christian Period Nubia.Nature communications · 2021Article
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- Positive selection in admixed populations from Ethiopia.BMC genetics · 2020Article
- The shaping of immunological responses through natural selection after the Roma Diaspora.Scientific reports · 2020Article
- African evolutionary history inferred from whole genome sequence data of 44 indigenous African populations.Genome biology · 2019Article
- Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt".PLoS genetics · 2019Article
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- Genetic history of Chad.American journal of physical anthropology · 2018Article
- African genetic diversity provides novel insights into evolutionary history and local adaptations.Human molecular genetics · 2018Review
- A novel mutation in the TG gene (G2322S) causing congenital hypothyroidism in a Sudanese family: a case report.BMC medical genetics · 2018Article
- Northeast African genomic variation shaped by the continuity of indigenous groups and Eurasian migrations.PLoS genetics · 2017Article
- Migration Route Out of Africa Unresolved by 225 Egyptian and Ethiopian Whole Genome Sequences.Frontiers in genetics · 2016Article
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
East Africa is a strategic region to study human genetic diversity due to the presence of ethnically, linguistically, and geographically diverse populations. Here, we provide new insight into the genetic history of populations living in the Sudanese region of East Africa by analysing nine ethnic groups belonging to three African linguistic families: Niger-Kordofanian, Nilo-Saharan and Afro-Asiatic. A total of 500 individuals were genotyped for 200,000 single-nucleotide polymorphisms. Principal component analysis, clustering analysis using ADMIXTURE, FST statistics, and the three-population test were used to investigate the underlying genetic structure and ancestry of the different ethno-linguistic groups. Our analyses revealed a genetic component for Sudanese Nilo-Saharan speaking groups (Darfurians and part of Nuba populations) related to Nilotes of South Sudan, but not to other Sudanese populations or other sub-Saharan populations. Populations inhabiting the North of the region showed close genetic affinities with North Africa, with a component that could be remnant of North Africans before the migrations of Arabs from Arabia. In addition, we found very low genetic distances between populations in genes important for anti-malarial and anti-bacterial host defence, suggesting similar selective pressures on these genes and stressing the importance of considering functional pathways to understand the evolutionary history of populations.
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