Trial reportAmerican journal of hematology2015
Bone marrow necrosis in acute leukemia: Clinical characteristic and outcome.
Trial report in American journal of hematology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Acute lymphoblastic leukemia with bone marrow necrosis as the first clinical manifestation: a pediatric case report.Frontiers in oncology · 2026Article
- Fever of Unknown Origin Unveiling Bone Marrow Necrosis Secondary to Diffuse Large B-cell Lymphoma.Cureus · 2025Article
- Medullary Necrosis in Acute Leukemia Mimicking as JIA.Indian journal of pediatrics · 2024Article
- Diagnosis of Bone Marrow Necrosis following Severe Vaso-Occlusive Crisis in Patient with Compound Heterozygous Sickle Cell Disease.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Article
- The feasibility of PETHEMA ALL-96 regimen on treatment of patients with acute lymphoid leukemia.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Article
- Two cases of follicular lymphoma with MYC gene abnormalities that presented with bone marrow necrosis.Journal of clinical and experimental hematopathology : JCEH · 2022Article
- Bone marrow necrosis as complication of treatment with all-trans retinoic acid and arsenic trioxide: case report and implications for treatment.Annals of hematology · 2022Article
- Intussusception in a child with Acute Lymphoblastic Leukemia: a remarkable presentation with literature review - a case report.Journal of the Egyptian National Cancer Institute · 2021Review
- Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis.Internal medicine (Tokyo, Japan) · 2021Review
- Rapid resolution of bone marrow necrosis mimicking relapse of pediatric acute lymphoblastic leukemia.Blood research · 2020Article
- Extensive Bone Marrow Necrosis: A Rare Presentation of Acute Lymphoblastic Leukaemia.Case reports in hematology · 2020Article
- Massive bone marrow necrosis revealing an HIV-related primary bone marrow lymphoma: a diagnostic challenge.International journal of hematology · 2019Article
- STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.Cell reports · 2018Article
- Bone Marrow Necrosis in Newly Diagnosed Acute Leukemia: Two Case Reports and Review of the Literature.Oncology and therapy · 2017Article
- Article
- Article
- Multiple Myeloma: An Unusual Cause of Extensive Bone Marrow Necrosis.Journal of clinical and diagnostic research : JCDR · 2016Article
- Acute myeloid leukemia presenting with extensive bone marrow necrosis, leukemia cutis and testicular involvement: successful treatment with allogeneic hematopoietic stem cell transplantation.Bone marrow transplantation · 2016Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
Abstract
Bone marrow necrosis (BMN) is characterized by infarction of the medullary stroma, leading to marrow necrosis with preserved cortical bone. In reported small series, BMN in hematological malignancies is associated with poor prognosis. We sought to find the impact of BMN on clinical outcome in a relatively larger cohort of patients with acute leukemias. Overall we evaluated 1,691 patients; 1,051 with acute myeloid leukemia (AML) and 640 with acute lymphocytic leukemia referred to our institution between 2002 and 2013. Patients with AML and acute lymphoblastic leukemia (ALL) were evaluated separately to determine the incidence of BMN, associated clinical features and its prognostic significance. At initial diagnosis, BMN was observed in 25 (2.4%) patients with AML and 20 (3.2%) patients with ALL. In AML, BMN was significantly associated with French-American-British AML M5 morphology (32% vs. 10%, P = 0.002). The complete remission (CR) rate in AML with and without BMN was 32% and 59% respectively (P = 0.008). Likewise, CR rate in ALL with BMN was also inferior, 70% vs. 92% (P = 0.005). The median overall survival (OS) in AML with BMN was significantly poorer, 3.7 months compared to 14 months without BMN (P = 0.003). Similarly, the median OS in ALL with and without BMN was 61.7 and 72 months respectively (P = 0.33). BMN is not a rare entity in AML and ALL, but is infrequent. BMN in AML and in ALL is suggestive of inferior response and poor prognosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.